J Physiol Society Membership
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Physiology in Press

First published online on February 7, 2003.
 Copyright © 2003 by The Physiological Society
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
547/2/333    most recent
2002.034140v1
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Parekh, A. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Parekh, A. B.

Received October 9, 2002
Accepted after revision December 17, 2002

Store-operated Ca2+ entry: dynamic interplay between endoplasmic reticulum, mitochondria and plasma membrane

A. B. Parekh1*

1 Department of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK

* To whom correspondence should be addressed. E-mail: anant.parekh{at}physiol.ox.ac.uk.

In eukaryotic cells, hormones and neurotransmitters that engage the phosphoinositide pathway evoke a biphasic increase in intracellular free Ca2+ concentration: an initial transient release of Ca2+ from intracellular stores is followed by a sustained phase of Ca2+ influx. This influx is generally store-dependent and is required for controlling a host of Ca2+-dependent processes ranging from exocytosis to cell growth and proliferation. In many cell types, store-operated Ca2+ entry is manifest as a non-voltage-gated Ca2+ current called ICRAC (Ca2+ release-activated Ca2+ current). Just how store emptying activates CRAC channels remains unclear, and some of our recent experiments that address this issue will be described. No less important from a physiological perspective is the weak Ca2+ buffer paradox: whereas macroscopic (whole cell) ICRAC can be measured routinely in the presence of strong intracellular Ca2+ buffer, the current is generally not detectable under physiological conditions of weak buffering following store emptying with the second messenger InsP3. In this review, I describe some of our experiments aimed at understanding just why InsP3 is ineffective under these conditions and which lead us to conclude that respiring mitochondria are essential for the activation of ICRAC in weak intracellular Ca2+ buffer. Mitochondrial Ca2+ uptake also increases the dynamic range over which InsP3 functions as the second messenger that controls Ca2+ influx. Finally, we find that Ca2+-dependent slow inactivation of Ca2+ influx, a widespread but poorly understood phenomenon that helps shape the profile of an intracellular Ca2+ signal, is regulated by mitochondrial Ca2+ buffering. Thus, by enabling macroscopic store-operated Ca2+ current to activate and then by controlling its extent and duration, mitochondria play a crucial role in all stages of store-operated Ca2+ influx. Store-operated Ca2+ entry reflects therefore a dynamic interplay between endoplasmic reticulum, mitochondria and plasma membrane.




This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
R. Malli, S. Naghdi, C. Romanin, and W. F. Graier
Cytosolic Ca2+ prevents the subplasmalemmal clustering of STIM1: an intrinsic mechanism to avoid Ca2+ overload
J. Cell Sci., October 1, 2008; 121(19): 3133 - 3139.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
T. L. Lewis, K. M. Brundage, R. A. Brundage, and J. B. Barnett
3,4-Dichloropropionanilide (DCPA) Inhibits T-Cell Activation by Altering the Intracellular Calcium Concentration following Store Depletion
Toxicol. Sci., May 1, 2008; 103(1): 97 - 107.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S.-M. Jangi, M.B. Ruiz-Larrea, F. Nicolau-Galmes, N. Andollo, Y. Arroyo-Berdugo, I. Ortega-Martinez, J. L. Diaz-Perez, and M. D. Boyano
Terfenadine-induced apoptosis in human melanoma cells is mediated through Ca2+ homeostasis modulation and tyrosine kinase activity, independently of H1 histamine receptors
Carcinogenesis, March 1, 2008; 29(3): 500 - 509.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
E. Abad, G. Lorente, N. Gavara, M. Morales, A. Gual, and X. Gasull
Activation of Store-Operated Ca2+ Channels in Trabecular Meshwork Cells
Invest. Ophthalmol. Vis. Sci., February 1, 2008; 49(2): 677 - 686.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
B. M. Walsh, H. B. Naik, J. M. Dubach, M. Beshire, A. M. Wieland, and D. I. Soybel
Thiol-oxidant monochloramine mobilizes intracellular Ca2+ in parietal cells of rabbit gastric glands
Am J Physiol Cell Physiol, November 1, 2007; 293(5): C1687 - C1697.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W.-C. Chang, J. Di Capite, C. Nelson, and A. B. Parekh
All-or-None Activation of CRAC Channels by Agonist Elicits Graded Responses in Populations of Mast Cells
J. Immunol., October 15, 2007; 179(8): 5255 - 5263.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Hong and W. N. Ross
Priming of intracellular calcium stores in rat CA1 pyramidal neurons
J. Physiol., October 1, 2007; 584(1): 75 - 87.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Caplanusi, A. J. Fuller, R. A. Gonzalez-Villalobos, T. G. Hammond, and L. G. Navar
Metabolic inhibition-induced transient Ca2+ increase depends on mitochondria in a human proximal renal cell line
Am J Physiol Renal Physiol, August 1, 2007; 293(2): F533 - F540.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. L. Ong, X. Liu, K. Tsaneva-Atanasova, B. B. Singh, B. C. Bandyopadhyay, W. D. Swaim, J. T. Russell, R. S. Hegde, A. Sherman, and I. S. Ambudkar
Relocalization of STIM1 for Activation of Store-operated Ca2+ Entry Is Determined by the Depletion of Subplasma Membrane Endoplasmic Reticulum Ca2+ Store
J. Biol. Chem., April 20, 2007; 282(16): 12176 - 12185.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C. Dell'Agnello, S. Leo, A. Agostino, G. Szabadkai, C. Tiveron, A. Zulian, A. Prelle, P. Roubertoux, R. Rizzuto, and M. Zeviani
Increased longevity and refractoriness to Ca2+-dependent neurodegeneration in Surf1 knockout mice
Hum. Mol. Genet., February 15, 2007; 16(4): 431 - 444.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. Kuba, Y. Higure, H. Susaki, R. Hayato, and K. Kuba
Bidirectional Ca2+ coupling of mitochondria with the endoplasmic reticulum and regulation of multimodal Ca2+ entries in rat brown adipocytes
Am J Physiol Cell Physiol, February 1, 2007; 292(2): C896 - C908.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. J. Jennings Jr., J.-h. Zhu, Y. Rbaibi, X. Luo, C. T. Chu, and K. Kiselyov
Mitochondrial Aberrations in Mucolipidosis Type IV
J. Biol. Chem., December 22, 2006; 281(51): 39041 - 39050.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. A. Kachoei, R. J. Knox, D. Uthuza, S. Levy, L. K. Kaczmarek, and N. S. Magoski
A Store-Operated Ca2+ Influx Pathway in the Bag Cell Neurons of Aplysia
J Neurophysiol, November 1, 2006; 96(5): 2688 - 2698.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
C. V. Remillard and J. X.-J. Yuan
Transient Receptor Potential Channels and Caveolin-1: Good Friends in Tight Spaces
Mol. Pharmacol., October 1, 2006; 70(4): 1151 - 1154.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
D. A. Rusakov
Ca2+-Dependent Mechanisms of Presynaptic Control at Central Synapses
Neuroscientist, August 1, 2006; 12(4): 317 - 326.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
R. Scott and D. A. Rusakov
Main determinants of presynaptic Ca2+ dynamics at individual mossy fiber-CA3 pyramidal cell synapses.
J. Neurosci., June 28, 2006; 26(26): 7071 - 7081.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
G. K. Rao and N. E. Kaminski
Cannabinoid-Mediated Elevation of Intracellular Calcium: A Structure-Activity Relationship
J. Pharmacol. Exp. Ther., May 1, 2006; 317(2): 820 - 829.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. S. Ada-Nguema, H. Xenias, M. P. Sheetz, and P. J. Keely
The small GTPase R-Ras regulates organization of actin and drives membrane protrusions through the activity of PLC{epsilon}
J. Cell Sci., April 1, 2006; 119(7): 1307 - 1319.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. Hughes, A. K. Lee, and A. Tse
Dominant Role of Sarcoendoplasmic Reticulum Ca2+-ATPase Pump in Ca2+ Homeostasis and Exocytosis in Rat Pancreatic {beta}-Cells
Endocrinology, March 1, 2006; 147(3): 1396 - 1407.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
L. Nunez, R. A. Valero, L. Senovilla, S. Sanz-Blasco, J. Garcia-Sancho, and C. Villalobos
Cell proliferation depends on mitochondrial Ca2+ uptake: inhibition by salicylate
J. Physiol., February 15, 2006; 571(1): 57 - 73.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
J. M. A. M. Kusters, M. M. Dernison, W. P. M. van Meerwijk, D. L. Ypey, A. P. R. Theuvenet, and C. C. A. M. Gielen
Stabilizing Role of Calcium Store-Dependent Plasma Membrane Calcium Channels in Action-Potential Firing and Intracellular Calcium Oscillations
Biophys. J., December 1, 2005; 89(6): 3741 - 3756.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. M. Hurne, J. J. O'Brien, D. Wingrove, G. Cherednichenko, P. D. Allen, K. G. Beam, and I. N. Pessah
Ryanodine Receptor Type 1 (RyR1) Mutations C4958S and C4961S Reveal Excitation-coupled Calcium Entry (ECCE) Is Independent of Sarcoplasmic Reticulum Store Depletion
J. Biol. Chem., November 4, 2005; 280(44): 36994 - 37004.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
V. A. Golovina
Visualization of localized store-operated calcium entry in mouse astrocytes. Close proximity to the endoplasmic reticulum
J. Physiol., May 1, 2005; 564(3): 737 - 749.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Lin, P. Varnai, G. Csordas, A. Balla, T. Nagai, A. Miyawaki, T. Balla, and G. Hajnoczky
Control of Calcium Signal Propagation to the Mitochondria by Inositol 1,4,5-Trisphosphate-binding Proteins
J. Biol. Chem., April 1, 2005; 280(13): 12820 - 12832.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. M. Power and P. Sah
Intracellular calcium store filling by an L-type calcium current in the basolateral amygdala at subthreshold membrane potentials
J. Physiol., January 15, 2005; 562(2): 439 - 453.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. Verkhratsky
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
Physiol Rev, January 1, 2005; 85(1): 201 - 279.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Aneiros, S. Philipp, A. Lis, M. Freichel, and A. Cavalie
Modulation of Ca2+ Signaling by Na+/Ca2+ Exchangers in Mast Cells
J. Immunol., January 1, 2005; 174(1): 119 - 130.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
R. Laporte, A. Hui, and I. Laher
Pharmacological Modulation of Sarcoplasmic Reticulum Function in Smooth Muscle
Pharmacol. Rev., December 1, 2004; 56(4): 439 - 513.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. Yi, D. Weaver, and G. Hajnoczky
Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit
J. Cell Biol., November 22, 2004; 167(4): 661 - 672.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
K. AYUB and M. B. HALLETT
The mitochondrial ADPR link between Ca2+ store release and Ca2+ influx channel opening in immune cells
FASEB J, September 1, 2004; 18(12): 1335 - 1338.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. I. Zakharov, T. Smani, Y. Dobrydneva, F. Monje, C. Fichandler, P. F. Blackmore, and V. M. Bolotina
Diethylstilbestrol Is a Potent Inhibitor of Store-Operated Channels and Capacitative Ca2+ Influx
Mol. Pharmacol., September 1, 2004; 66(3): 702 - 707.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
I. S. Ambudkar
Cellular Domains That Contribute to Ca2+ Entry Events
Sci. Signal., July 27, 2004; 2004(243): pe32 - pe32.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W.-C. Chang and A. B. Parekh
Close Functional Coupling between Ca2+ Release-activated Ca2+ Channels, Arachidonic Acid Release, and Leukotriene C4 Secretion
J. Biol. Chem., July 16, 2004; 279(29): 29994 - 29999.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
G. Isenberg
Ca2+ Control of Transcription: Can We Extrapolate Signaling Cascades From Neurons to Vascular Smooth Muscle Cells?
Circ. Res., May 28, 2004; 94(10): 1276 - 1278.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Liu, S. Mather, Y. Huang, C. J. Garland, and X. Yao
Extracellular ATP facilitates flow-induced vasodilatation in rat small mesenteric arteries
Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1688 - H1695.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. R. Duchen
Roles of Mitochondria in Health and Disease
Diabetes, February 1, 2004; 53(90001): S96 - 102.
[Abstract] [Full Text]

Home page
 Sci SignalHome page
R. Rizzuto, M. R. Duchen, and T. Pozzan
Flirting in Little Space: The ER/Mitochondria Ca2+ Liaison
Sci. Signal., January 13, 2004; 2004(215): re1 - re1.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Li, R. E. Feltzer, K. L. Dawson, E. A. Hudson, and B. J. Clark
Janus Kinase 2 and Calcium Are Required for Angiotensin II-dependent Activation of Steroidogenic Acute Regulatory Protein Transcription in H295R Human Adrenocortical Cells
J. Biol. Chem., December 26, 2003; 278(52): 52355 - 52362.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
A. B. Parekh
Mitochondrial Regulation of Intracellular Ca2+ Signaling: More Than Just Simple Ca2+ Buffers
Physiology, December 1, 2003; 18(6): 252 - 256.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Malli, M. Frieden, K. Osibow, C. Zoratti, M. Mayer, N. Demaurex, and W. F. Graier
Sustained Ca2+ Transfer across Mitochondria Is Essential for Mitochondrial Ca2+ Buffering, Store-operated Ca2+ Entry, and Ca2+ Store Refilling
J. Biol. Chem., November 7, 2003; 278(45): 44769 - 44779.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
R. E. Carraway, X. Gui, and D. E. Cochrane
Ca2+ Channel Blockers Enhance Neurotensin (NT) Binding and Inhibit NT-Induced Inositol Phosphate Formation in Prostate Cancer PC3 Cells
J. Pharmacol. Exp. Ther., November 1, 2003; 307(2): 640 - 650.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2003 The Physiological Society.