| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Received December 31, 2002
Accepted after revision April 4, 2003
1 Department of Zoology, Box 351800, University of Washington, Seattle, WA 98195-1800, USA
2 Department of Biology, Box 351800, University of Washington, Seattle, WA 98195-1800, USA
* To whom correspondence should be addressed. E-mail: martibee{at}u.washington.edu.
Spontaneous electrical activity synchronized among groups of related neurons is a widespread and important feature of central nervous system development. Among the many places from which spontaneous rhythmic activity has been recorded early in development are the cranial motor nerve roots that exit the hindbrain, the motor neuron pool that, at birth, will control the rhythmic motor patterns of swallow, feeding and the oral components of respiratory behavior. Understanding the mechanism and significance of this hindbrain activity, however, has been hampered by the difficulty of identifying and recording from individual hindbrain motor neurons in living tissue. We have used retrograde labelling to identify living cranial branchiomeric motor neurons in the hindbrain, and [Ca2+]i imaging of such labelled cells to measure spontaneous activity simultaneously in groups of motor neuron somata. We find that branchiomeric motor neurons of the trigeminal and facial nerves generate spontaneous [Ca2+]i transients throughout the developmental period E9.5 to E11.5. During this two-day period the activity changes from low-frequency, long-duration events that are tetrodotoxin insensitive and poorly coordinated among cells, to high-frequency short-duration events that are tetrodotoxin sensitive and tightly coordinated thoughout the motor neuron population. This early synchronization may be crucial for correct neuron-target development.
This article has been cited by other articles:
|
|
 |
|
  M. Thoby-Brisson and J. J. Greer Anatomical and functional development of the pre-Botzinger complex in prenatal rodents J Appl Physiol, April 1, 2008; 104(4): 1213 - 1219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Crandall, M. Adam, A. K. Kinnischtzke, and T. A. Nick HVC Neural Sleep Activity Increases With Development and Parallels Nightly Changes in Song Behavior J Neurophysiol, July 1, 2007; 98(1): 232 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. McCabe, S. L. Chisholm, H. L. Picken-Bahrey, and W. J. Moody The self-regulating nature of spontaneous synchronized activity in developing mouse cortical neurones J. Physiol., November 15, 2006; 577(1): 155 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. N Hunt, A. K McCabe, and M. M Bosma Midline serotonergic neurones contribute to widespread synchronized activity in embryonic mouse hindbrain J. Physiol., August 1, 2005; 566(3): 807 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Moody and M. M. Bosma Ion Channel Development, Spontaneous Activity, and Activity-Dependent Development in Nerve and Muscle Cells Physiol Rev, July 1, 2005; 85(3): 883 - 941. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Thoby-Brisson, J.-B. Trinh, J. Champagnat, and G. Fortin Emergence of the Pre-Botzinger Respiratory Rhythm Generator in the Mouse Embryo J. Neurosci., April 27, 2005; 25(17): 4307 - 4318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Corlew, M. M Bosma, and W. J Moody Spontaneous, synchronous electrical activity in neonatal mouse cortical neurones J. Physiol., October 15, 2004; 560(2): 377 - 390. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
