HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by McCloskey, D. I. Articles by Mitchell, J. H. Search for Related Content PubMed PubMed Citation Articles by McCloskey, D. I. Articles by Mitchell, J. H.

1. In anaesthetized and decerebrate cats isometric exercise of the hind limb muscles was elicited by stimulating the spinal ventral roots L7-S1. This caused a rise in arterial blood pressure, with small increases in heart rate and pulmonary ventilation. These changes were abolished by cutting the dorsal roots receiving afferents from the exercising muscle.

2. When the triceps surae muscle was made to exercise by ventral root stimulation, occlusion of the femoral artery and vein through and beyond the period of exercise caused the blood pressure to remain raised until the occlusion was removed. The ventilatory and heart rate responses were not markedly altered or prolonged by such circulatory occlusion.

3. Injection of small volumes of 5% NaCl or isotonic KCl into the arterial blood supplying hind limb muscles gave cardiovascular and respiratory responses similar to those evoked by exercise. Like the responses to exercise, these responses were abolished by dorsal root section.

4. Direct current anodal block of the dorsal roots receiving afferents from the exercising muscle was used to block preferentially large myelinated fibres: this form of block did not abolish the evoked cardiovascular and respiratory responses. Local anaesthetic block of the dorsal roots was used to block preferentially unmyelinated and small myelinated fibres: this form of block abolished the cardiovascular and respiratory responses. It is concluded that the reflex responses are mediated by fibres within groups III and IV (small myelinated fibres and unmyelinated fibres).

This article has been cited by other articles:

				A. K. Leal, M. A. Williams, M. G. Garry, J. H. Mitchell, and S. A. Smith Evidence for functional alterations in the skeletal muscle mechanoreflex and metaboreflex in hypertensive rats Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1429 - H1438. [Abstract] [Full Text] [PDF]

				S. G. Hayes, J. L. McCord, J. Rainier, Z. Liu, and M. P. Kaufman Role played by acid-sensitive ion channels in evoking the exercise pressor reflex Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1720 - H1725. [Abstract] [Full Text] [PDF]

				A. R. Light, R. W. Hughen, J. Zhang, J. Rainier, Z. Liu, and J. Lee Dorsal Root Ganglion Neurons Innervating Skeletal Muscle Respond to Physiological Combinations of Protons, ATP, and Lactate Mediated by ASIC, P2X, and TRPV1 J Neurophysiol, September 1, 2008; 100(3): 1184 - 1201. [Abstract] [Full Text] [PDF]

				M. P. Kaufman and S. G. Hayes Receptor Synergy From Thin Fiber Muscle Afferents. Focus on "Dorsal Root Ganglion Neurons Innervating Skeletal Muscle Respond to Physiological Combinations of Protons, ATP, and Lactate Mediated by ASIC, P2X, and TRPV1" J Neurophysiol, September 1, 2008; 100(3): 1169 - 1170. [Full Text] [PDF]

				J. L. McCord, S. G. Hayes, and M. P. Kaufman Acid-sensing ion and epithelial sodium channels do not contribute to the mechanoreceptor component of the exercise pressor reflex Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1017 - H1024. [Abstract] [Full Text] [PDF]

				J. Xing, L. Sinoway, and J. Li Differential responses of sensory neurones innervating glycolytic and oxidative muscle to protons and capsaicin J. Physiol., July 1, 2008; 586(13): 3245 - 3252. [Abstract] [Full Text] [PDF]

				J. Cui, R. Moradkhan, V. Mascarenhas, A. Momen, and L. I. Sinoway Cyclooxygenase inhibition attenuates sympathetic responses to muscle stretch in humans Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2693 - H2700. [Abstract] [Full Text] [PDF]

				Z. Gao, S. Koba, L. Sinoway, and J. Li 20-HETE increases renal sympathetic nerve activity via activation of chemically and mechanically sensitive muscle afferents J. Physiol., May 15, 2008; 586(10): 2581 - 2591. [Abstract] [Full Text] [PDF]

				A. Momen, J. Cui, P. McQuillan, and L. I. Sinoway Local prostaglandin blockade attenuates muscle mechanoreflex-mediated renal vasoconstriction during muscle stretch in humans Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2184 - H2190. [Abstract] [Full Text] [PDF]

				J. P. Fisher, C. N. Young, and P. J. Fadel Effect of muscle metaboreflex activation on carotid-cardiac baroreflex function in humans Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2296 - H2304. [Abstract] [Full Text] [PDF]

				J. Cui, V. Mascarenhas, R. Moradkhan, C. Blaha, and L. I. Sinoway Effects of muscle metabolites on responses of muscle sympathetic nerve activity to mechanoreceptor(s) stimulation in healthy humans Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R458 - R466. [Abstract] [Full Text] [PDF]

				M. A. Williams, S. A. Smith, D. E. O'Brien, J. H. Mitchell, and M. G. Garry The group IV afferent neuron expresses multiple receptor alterations in cardiomyopathyic rats: evidence at the cannabinoid CB1 receptor J. Physiol., February 1, 2008; 586(3): 835 - 845. [Abstract] [Full Text] [PDF]

				A. E. Kindig, S. G. Hayes, and M. P. Kaufman Blockade of purinergic 2 receptors attenuates the mechanoreceptor component of the exercise pressor reflex Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2995 - H3000. [Abstract] [Full Text] [PDF]

				S. Koba, J. Xing, L. I. Sinoway, and J. Li Differential sympathetic outflow elicited by active muscle in rats Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2335 - H2343. [Abstract] [Full Text] [PDF]

				J. P. Fisher, S. Ogoh, C. N. Young, D. M. Keller, and P. J. Fadel Exercise intensity influences cardiac baroreflex function at the onset of isometric exercise in humans J Appl Physiol, September 1, 2007; 103(3): 941 - 947. [Abstract] [Full Text] [PDF]

				J. Cui, P. McQuillan, A. Momen, C. Blaha, R. Moradkhan, V. Mascarenhas, C. Hogeman, A. Krishnan, and L. I. Sinoway The role of the cyclooxygenase products in evoking sympathetic activation in exercise Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1861 - H1868. [Abstract] [Full Text] [PDF]

				J. M. Stewart, I. Taneja, and M. S. Medow Reduced central blood volume and cardiac output and increased vascular resistance during static handgrip exercise in postural tachycardia syndrome Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1908 - H1917. [Abstract] [Full Text] [PDF]

				M. Herigstad, G. M. Balanos, and P. A. Robbins Can human cardiovascular regulation during exercise be learnt from feedback from arterial baroreceptors? Exp Physiol, July 1, 2007; 92(4): 695 - 704. [Abstract] [Full Text] [PDF]

				Z. Gao, J. D. Li, L. I. Sinoway, and J. Li Effect of muscle interstitial pH on P2X and TRPV1 receptor-mediated pressor response J Appl Physiol, June 1, 2007; 102(6): 2288 - 2293. [Abstract] [Full Text] [PDF]

				S. P. Dufour, S. Doutreleau, E. Lonsdorfer-Wolf, E. Lampert, C. Hirth, F. Piquard, J. Lonsdorfer, B. Geny, B. Mettauer, and R. Richard Deciphering the metabolic and mechanical contributions to the exercise-induced circulatory response: insights from eccentric cycling Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1641 - R1648. [Abstract] [Full Text] [PDF]

				M. F. Piepoli and A. J. S. Coats COUNTERPOINT: INCREASED METABORECEPTOR STIMULATION EXPLAINS THE EXAGGERATED EXERCISE PRESSOR REFLEX SEEN IN HEART FAILURE J Appl Physiol, January 1, 2007; 102(1): 494 - 496. [Full Text] [PDF]

				M. G. Garry, S. A. Smith, and J. H. Mitchell Increased mechanoreceptor/metaboreceptor stimulation explains the exaggerated exercise pressor reflex seen in heart failure J Appl Physiol, January 1, 2007; 102(1): 502 - 502. [Full Text] [PDF]

				A. E. Kindig, S. G. Hayes, and M. P. Kaufman Purinergic 2 receptor blockade prevents the responses of group IV afferents to post-contraction circulatory occlusion J. Physiol., January 1, 2007; 578(1): 301 - 308. [Abstract] [Full Text] [PDF]

				J. M. Stewart, L. D. Montgomery, J. L. Glover, and M. S. Medow Changes in regional blood volume and blood flow during static handgrip Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H215 - H223. [Abstract] [Full Text] [PDF]

				M. P. Kaufman Mechanoreceptors and central command Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H117 - H118. [Full Text] [PDF]

				S. A. Smith, M. A. Williams, A. K. Leal, J. H. Mitchell, and M. G. Garry Exercise pressor reflex function is altered in spontaneously hypertensive rats J. Physiol., December 15, 2006; 577(3): 1009 - 1020. [Abstract] [Full Text] [PDF]

				J. Cui, C. Blaha, R. Moradkhan, K. S. Gray, and L. I. Sinoway Muscle sympathetic nerve activity responses to dynamic passive muscle stretch in humans J. Physiol., October 15, 2006; 576(2): 625 - 634. [Abstract] [Full Text] [PDF]

				Z. Gao, V. Kehoe, J. Xing, L. Sinoway, and J. Li Temperature modulates P2X receptor-mediated cardiovascular responses to muscle afferent activation Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1255 - H1261. [Abstract] [Full Text] [PDF]

				M. F. Piepoli, A. Kaczmarek, D. P. Francis, L. C. Davies, M. Rauchhaus, E. A. Jankowska, S. D. Anker, A. Capucci, W. Banasiak, and P. Ponikowski Reduced Peripheral Skeletal Muscle Mass and Abnormal Reflex Physiology in Chronic Heart Failure Circulation, July 11, 2006; 114(2): 126 - 134. [Abstract] [Full Text] [PDF]

				S. G. Hayes, A. E. Kindig, and M. P. Kaufman Cyclooxygenase blockade attenuates responses of group III and IV muscle afferents to dynamic exercise in cats Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2239 - H2246. [Abstract] [Full Text] [PDF]

				D. D. Sheriff Baroreflex resetting during exercise: mechanisms and meaning Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1406 - H1407. [Full Text] [PDF]

				A. E. Kindig, S. G. Hayes, R. L. Hanna, and M. P. Kaufman P2 antagonist PPADS attenuates responses of thin fiber afferents to static contraction and tendon stretch Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1214 - H1219. [Abstract] [Full Text] [PDF]

				Z. Gao, O. Henig, V. Kehoe, L. I. Sinoway, and J. Li Vanilloid type 1 receptor and the acid-sensing ion channel mediate acid phosphate activation of muscle afferent nerves in rats J Appl Physiol, February 1, 2006; 100(2): 421 - 426. [Abstract] [Full Text] [PDF]

				J. W Williamson, P. J Fadel, and J. H Mitchell New insights into central cardiovascular control during exercise in humans: a central command update Exp Physiol, January 1, 2006; 91(1): 51 - 58. [Abstract] [Full Text] [PDF]

				K. M Gallagher, P. J Fadel, S. A Smith, M. Stromstad, K. Ide, N. H Secher, and P. B Raven The interaction of central command and the exercise pressor reflex in mediating baroreflex resetting during exercise in humans Exp Physiol, January 1, 2006; 91(1): 79 - 87. [Abstract] [Full Text] [PDF]

				S. A Smith, J. H Mitchell, and M. G Garry The mammalian exercise pressor reflex in health and disease Exp Physiol, January 1, 2006; 91(1): 89 - 102. [Abstract] [Full Text] [PDF]

				S. Koba, T. Yoshida, and N. Hayashi Renal sympathetic and circulatory responses to activation of the exercise pressor reflex in rats Exp Physiol, January 1, 2006; 91(1): 111 - 119. [Abstract] [Full Text] [PDF]

				P. Haouzi and B. Chenuel Control of arterial PCO2 by somatic afferents in sheep J. Physiol., December 15, 2005; 569(3): 975 - 987. [Abstract] [Full Text] [PDF]

				J. H. Coote Found in translation: neural feedback from exercising muscles J. Physiol., December 1, 2005; 569(2): 707 - 707. [Full Text] [PDF]

				M. J. Joyner Reply from M. J. Joyner J. Physiol., December 1, 2005; 569(2): 708 - 708. [Full Text] [PDF]

				J.-K. Kim, J. A. Sala-Mercado, R. L. Hammond, J. Rodriguez, T. J. Scislo, and D. S. O'Leary Attenuated arterial baroreflex buffering of muscle metaboreflex in heart failure Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2416 - H2423. [Abstract] [Full Text] [PDF]

				A. M. Degtyarenko and M. P. Kaufman MLR-induced inhibition of barosensory cells in the NTS Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2575 - H2584. [Abstract] [Full Text] [PDF]

				S. G. Hayes, A. E. Kindig, and M. P. Kaufman Comparison between the effect of static contraction and tendon stretch on the discharge of group III and IV muscle afferents J Appl Physiol, November 1, 2005; 99(5): 1891 - 1896. [Abstract] [Full Text] [PDF]

				S. A. Smith, J. H. Mitchell, R. H. Naseem, and M. G. Garry Mechanoreflex Mediates the Exaggerated Exercise Pressor Reflex in Heart Failure Circulation, October 11, 2005; 112(15): 2293 - 2300. [Abstract] [Full Text] [PDF]

				N. Hayashi, S. Koba, and T. Yoshida Disuse atrophy increases the muscle mechanoreflex in rats J Appl Physiol, October 1, 2005; 99(4): 1442 - 1445. [Abstract] [Full Text] [PDF]

				K. Yamamoto, T. Kawada, A. Kamiya, H. Takaki, M. Sugimachi, and K. Sunagawa Static interaction between muscle mechanoreflex and arterial baroreflex in determining efferent sympathetic nerve activity Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1604 - H1609. [Abstract] [Full Text] [PDF]

				V. F. Gladwell, J. Fletcher, N. Patel, L. J. Elvidge, D. Lloyd, S. Chowdhary, and J. H. Coote The influence of small fibre muscle mechanoreceptors on the cardiac vagus in humans J. Physiol., September 1, 2005; 567(2): 713 - 721. [Abstract] [Full Text] [PDF]

				M. J Joyner Found in translation: neural feedback from exercising muscles J. Physiol., September 1, 2005; 567(2): 362 - 363. [Full Text] [PDF]

				J. P Fisher, M. P. D Bell, and M. J White Cardiovascular responses to human calf muscle stretch during varying levels of muscle metaboreflex activation Exp Physiol, September 1, 2005; 90(5): 773 - 781. [Abstract] [Full Text] [PDF]

				L. I. Sinoway and J. Li A perspective on the muscle reflex: implications for congestive heart failure J Appl Physiol, July 1, 2005; 99(1): 5 - 22. [Abstract] [Full Text] [PDF]

				J. Li, N. C. King, and L. I. Sinoway Interstitial ATP and Norepinephrine Concentrations in Active Muscle Circulation, May 31, 2005; 111(21): 2748 - 2751. [Abstract] [Full Text] [PDF]

				M. P. D. Bell and M. J. White Cardiovascular responses to external compression of human calf muscle vary during graded metaboreflex stimulation Exp Physiol, May 1, 2005; 90(3): 383 - 391. [Abstract] [Full Text] [PDF]

				S. A. Smith, J. H. Mitchell, and J. Li Independent modification of baroreceptor and exercise pressor reflex function by nitric oxide in nucleus tractus solitarius Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2068 - H2076. [Abstract] [Full Text] [PDF]

				Z. Gao, V. Kehoe, L. I. Sinoway, and J. Li Spinal P2X receptor modulates reflex pressor response to activation of muscle afferents Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2238 - H2243. [Abstract] [Full Text] [PDF]

				S. A. Smith, M. A. Williams, J. H. Mitchell, P. P.A. Mammen, and M. G. Garry The Capsaicin-Sensitive Afferent Neuron in Skeletal Muscle Is Abnormal in Heart Failure Circulation, April 26, 2005; 111(16): 2056 - 2065. [Abstract] [Full Text] [PDF]

				A. E. Kindig, T. B. Heller, and M. P. Kaufman VR-1 receptor blockade attenuates the pressor response to capsaicin but has no effect on the pressor response to contraction in cats Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1867 - H1873. [Abstract] [Full Text] [PDF]

				J.-K. Kim, J. A. Sala-Mercado, J. Rodriguez, T. J. Scislo, and D. S. O'Leary Arterial baroreflex alters strength and mechanisms of muscle metaboreflex during dynamic exercise Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1374 - H1380. [Abstract] [Full Text] [PDF]

				J. T. Potts, I. A. Rybak, and J. F. R. Paton Respiratory Rhythm Entrainment by Somatic Afferent Stimulation J. Neurosci., February 23, 2005; 25(8): 1965 - 1978. [Abstract] [Full Text] [PDF]

				P. Boscan and J. F. R. Paton Excitatory convergence of periaqueductal gray and somatic afferents in the solitary tract nucleus: role for neurokinin 1 receptors Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R262 - R269. [Abstract] [Full Text] [PDF]

				M. J. Joyner Congestive Heart Failure: More Bad News From Exercising Muscle? Circulation, November 9, 2004; 110(19): 2978 - 2979. [Full Text] [PDF]

				J. Li, A. N. Sinoway, Z. Gao, M. D. Maile, M. Pu, and L. I. Sinoway Muscle Mechanoreflex and Metaboreflex Responses After Myocardial Infarction in Rats Circulation, November 9, 2004; 110(19): 3049 - 3054. [Abstract] [Full Text] [PDF]

				J. Li, M. D. Maile, A. N. Sinoway, and L. I. Sinoway Muscle pressor reflex: potential role of vanilloid type 1 receptor and acid-sensing ion channel J Appl Physiol, November 1, 2004; 97(5): 1709 - 1714. [Abstract] [Full Text] [PDF]