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J Physiol Volume 537, Number 3, 657-, December 12, 2001 DOI: 10.1113/jphysiol.2001.013478
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Journal of Physiology (2001), 537.3, pp. 657-657
© Copyright 2001 The Physiological Society

The creatine-phosphocreatine system: there's more than one song in its repertoire


Paul L. Greenhaff


School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK

As you read this you are probably well aware of the principal role of phosphocreatine (PCr) in skeletal muscle energy metabolism, namely that of a 'temporal' energy buffer at sites of high energy translocation which operates when the rate of ATP utilisation outstrips the rate of production by mitochondrial respiration. Thus, at the onset of steady-state contraction, or during non-steady-state conditions, PCr maintains ATP homeostasis at specific sites of high energy turnover (e.g. myofibrils; Fig. 1, Function 1), particularly in fast contracting skeletal muscle.


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