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Does NGF binding to p75 and trkA receptors activate independent signalling pathways to sensitize nociceptors?

L. M. Mendell

One important feature of nociceptors is their ability to undergo sensitization in response to damage of their receptive field. This sensitization is an important component of hyperalgesia, defined as an increase in the magnitude of the nociceptive response after some sensitizing event such as inflammation. Numerous investigators have demonstrated that this sensitization is the result of the release of substances into the vicinity of the nerve endings in the periphery. These substances include prostaglandin and nerve growth factor (NGF) and they have been shown to enhance the sensitivity of nociceptive neurons.