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This Article Full Text Full Text (PDF) All Versions of this Article: 555/1/297    most recent jphysiol.2003.054379v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gaigé, S. Articles by Bouvier, M. Search for Related Content PubMed PubMed Citation Articles by Gaigé, S. Articles by Bouvier, M.

Laboratoire de Physiologie Neurovégétative (UMR CNRS 6153, UMR INRA 1147), Faculté des Sciences et Techniques Saint-Jérôme, Université Aix-Marseille 3, Cases postales 351–352, Avenue Escadrille Normandie Niemen, 13397 Marseille Cedex 20, France

In a previous study, we established that leptin acts on chemosensitive intestinal vagal mechanoreceptors and that its excitatory effects are blocked by the endogenous interleukin-1ß receptor antagonist (Il-1ra). To determine how interleukin-1ß (Il-1ß) is involved in the action of leptin, we studied the effects of this drug on the single vagal afferent activities of intestinal mechanoreceptors in anaesthetized cats. For this purpose, the activity of 34 intestinal vagal mechanoreceptors was recorded via glass microelectrodes implanted in the nodose ganglion. Il-1ß (1 µg) administered into the artery irrigating the upper part of the intestine activated both the 16 leptin-activated units (type 1 units; P < 0.01) and the 12 leptin-inhibited units (type 2 units; P < 0.001), but had no effect on the six leptin-insensitive units. Cholecystokinin (CCK, 10 µg) induced an activatory response only in the two types of Il-1ß-sensitive units. When Il-1ß was administered after CCK, its excitatory effects on type 1 units were enhanced, whereas the excitatory effects on type 2 units were abolished. Pre-treatment with Il-1ra (250 µg) blocked all the effects of Il-1ß and the excitatory effects of leptin on type 1 units, whereas it enhanced the inhibitory effects of leptin on type 2 units. It can therefore be concluded that (i) leptin acts on intestinal vagal mechanoreceptors via Il-1ß in the case of the type 1 units and independently of Il-1ß in the case of the type 2 units, and (ii) type 1 and type 2 units belong to two different populations of vagal afferents that transmit different information about ingestion or inflammation to the CNS, depending on the chemical environment.

(Received 2 September 2003; accepted after revision 24 November 2003; first published online 28 November 2003)
Corresponding author M. Bouvier: Laboratoire de Physiologie Neurovégétative (UMR CNRS 6153, UMR INRA 1147), Faculté des Sciences et Techniques Saint-Jérôme, Université Aix-Marseille 3, Cases postales 351–352, Avenue Escadrille Normandie Niemen, 13397 Marseille Cedex 20, France. Email: michel.bouvier{at}univ.u-3mrs.fr

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