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1 Institute of Sports Medicine, Copenhagen, Bispebjerg Hospital, DK-2400 Copenhagen NV, Denmark
2 Team Danmark Test Center, Bispebjerg Hospital, DK-2400 Copenhagen NV, Denmark
3 Medical Research Laboratories, Aarhus University Hospital, DK-8000, Aarhus C, Denmark
4 Medical and Science Development Projects, Novo Nordisk A/S, DK-2880 Bagsværd, Denmark
The purpose of this study was to examine the effects of increased fat availability induced by growth hormone (GH) administration on the oxidative metabolism during exercise. Seven well-trained males (age 25 ± 2 years (mean ±
S.E.M.); peak oxygen consumption 
: 62 ± 1 ml min–1 kg–1 (completed four randomised trials: 120 min bicycling at 55%
4 h after receiving either 7.5 IU (2.5 mg) GH or placebo (Plc), and during rest after receiving either GH or Plc. In all studies a standardized meal was given 2 h after GH or Plc injection. GH administration resulted in an 
60-fold increase in serum GH concentration at rest (P < 0.0001) and during exercise (P < 0.0001). The increase in serum GH was followed by an increase in circulating glycerol at rest (8%, P < 0.0001). When combined with exercise the increase in plasma glycerol was more pronounced (GH: 716% of baseline versus Plc: 328%, P < 0.0001). However, this increase in fat mobilization did not increase fat oxidation during exercise (indirect calorimetry). In conclusion, GH administration combined with aerobic exercise increased lipolytic parameters substantially more than exercise alone, but did not further augment whole body fat oxidation.
(Received 29 April 2005;
accepted after revision 5 July 2005;
first published online 7 July 2005)
Corresponding author M. Hansen: Institute of Sports Medicine, Copenhagen, Building 8, Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark. Email: mh19{at}bbh.hosp.dk
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