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INTEGRATIVE |
1 Penn State Heart and Vascular Institute, General Clinical Research Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Baroreflex function is impaired in patients with obstructive sleep apnoea. We tested the hypothesis that short-term exposure to repetitive hypoxic apnoeas (RHA) produces prolonged impairment in baroreflex function. Baroreflex function was determined using the modified Oxford technique in 14 subjects (26 ± 1 years). Baroreflex sensitivity (BRS) was quantified from the R-R interval–systolic blood pressure (BP; cardiovagal BRS), heart rate–systolic BP (HR BRS) and muscle sympathetic nerve activity (MSNA)–diastolic BP (sympathetic BRS) relations. RHA involved subjects performing repetitive end-expiratory apnoeas (20 s) every minute for 30 min during intermittent hypoxia to accentuate oxygen desaturation. After RHA, BP and MSNA at rest were elevated. BRS was measured 
7 (Post 1), 30 (Post 2) and 50 min (Post 3) after RHA to provide insight into the temporal pattern of responses. Cardiovagal BRS (16.8 ± 1.3, 16.5 ± 1.6, 17.6 ± 2.0 and 17.4 ± 1.5 ms mmHg–1 for Pre, Post 1, Post 2 and Post 3, respectively), HR BRS (–1.1 ± 0.1, –1.1 ± 0.1, –1.3 ± 0.1 and –1.4 ± 0.1 beats min–1 mmHg–1) and sympathetic BRS (–4.5 ± 0.6, –4.4 ± 0.7, –3.7 ± 0.5 and –4.7 ± 1.0 arbitrary units (au) beat–1 mmHg–1) were unchanged by RHA. In contrast, the operating points of the baroreflexes were shifted rightward (to higher levels of BP) and upward (to higher levels of heart rate and MSNA) after RHA (P < 0.05). Time control studies performed in five additional subjects showed no change in any of the measured variables over time. Collectively, these data indicate that short-term exposure to RHA shifts (‘resets’) the baroreflex stimulus–response curve to higher levels of BP without influencing BRS for extended periods of time.
(Received 10 April 2006;
accepted after revision 16 May 2006;
first published online 18 May 2006)
Corresponding author K. D. Monahan: Penn State College of Medicine, Division of Cardiology H047, The Milton S. Hershey Medical Center, 500 University Dr., Hershey, PA 17033-2390, USA. Email: kmonahan{at}psu.edu
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