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This Article Full Text Full Text (PDF) All Versions of this Article: 575/2/361    most recent jphysiol.2006.113712v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yano, K. Articles by Robinson, H. P. C. Search for Related Content PubMed PubMed Citation Articles by Yano, K. Articles by Robinson, H. P. C. Related Collections Review articles

¹ Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK
² Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK

It is a challenging question to understand how different neuronal types are organized into a complex architecture in the cortex, an architecture which is also adapted in different regions to subserve very different functions. Recent developments in genetic and molecular techniques have opened up the possibility of using gene expression profiling for neuronal cell typing, with the aim of uncovering novel cell types and the underlying mechanisms which generate and maintain neuronal heterogeneity in the cortex. This review introduces some current ideas about neuronal cell types in the cortex and describes recent approaches to expression profiling for defining cortical neuronal cell types.

(Received 17 May 2006; accepted after revision 7 July 2006; first published online 13 July 2006)
Corresponding author H. P. C. Robinson: Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK. Email: hpcr{at}cam.ac.uk

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				E. Cherubini, S. Gustincich, and H. Robinson The mammalian transcriptome and the cellular complexity of the brain J. Physiol., September 1, 2006; 575(2): 319 - 320. [Full Text] [PDF]