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This Article Full Text Full Text (PDF) Supplemental data All Versions of this Article: 581/1/175    most recent jphysiol.2006.127068v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Metz, A. E. Articles by Martina, M. Search for Related Content PubMed PubMed Citation Articles by Metz, A. E. Articles by Martina, M. Related Collections Neuroscience

¹ Department of Physiology, Feinberg School of Medicine, Chicago, IL 60611, USA
² Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA

In CA1 pyramidal neurons, burst firing is correlated with hippocampally dependent behaviours and modulation of synaptic strength. One of the mechanisms underlying burst firing in these cells is the afterdepolarization (ADP) that follows each action potential. Previous work has shown that the ADP results from the interaction of several depolarizing and hyperpolarizing conductances located in the soma and the dendrites. By using patch-clamp recordings from acute rat hippocampal slices we show that D-type potassium current modulates the size of the ADP and the bursting of CA1 pyramidal neurons. Sensitivity to -dendrotoxin suggests that Kv1-containing potassium channels mediate this current. Dual somato-dendritic recording, outside-out dendritic recordings, and focal application of dendrotoxin together indicate that the channels mediating this current are located in the apical dendrites. Thus, our data present evidence for a dendritic segregation of Kv1-like channels in CA1 pyramidal neurons and identify a novel action for these channels, showing that they inhibit action potential bursting by restricting the size of the ADP.

(Received 19 December 2006; accepted after revision 20 February 2007; first published online 22 February 2007)
Corresponding author M. Martina: Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA.  Email: m-martina{at}northwestern.edu

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