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J Physiol Volume 581, Number 2, 619-629, June 1, 2007 DOI: 10.1113/jphysiol.2007.127860
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NEUROSCIENCE

Spino-dendritic cross-talk in rodent Purkinje neurons mediated by endogenous Ca2+-binding proteins

 Hartmut Schmidt1, Svenja Kunerth1, Christian Wilms1, Rainer Strotmann2 and Jens Eilers1

1 Carl-Ludwig-Institut für Physiologie, Liebigstrasse 27, 04103 Leipzig, Germany
2 Institut für Biochemie, Johannisallee 30, 04103 Leipzig, Germany

The range of actions of the second messenger Ca2+ is a key determinant of neuronal excitability and plasticity. For dendritic spines, there is on-going debate regarding how diffusional efflux of Ca2+ affects spine signalling. However, the consequences of spino-dendritic coupling for dendritic Ca2+ homeostasis and downstream signalling cascades have not been explored to date. We addressed this question by four-dimensional computer simulations, which were based on Ca2+-imaging data from mice that either express or lack distinct endogenous Ca2+-binding proteins. Our simulations revealed that single active spines do not affect dendritic Ca2+ signalling. Neighbouring, coactive spines, however, induce sizeable increases in dendritic [Ca2+]i when they process slow synaptic Ca2+ signals, such as those implicated in the induction of long-term plasticity. This spino-dendritic coupling is mediated by buffered diffusion, specifically by diffusing calbindin-bound Ca2+. This represents a central mechanism for activating calmodulin in dendritic shafts and therefore a novel form of signal integration in spiny dendrites.

(Received 9 January 2007; accepted after revision 6 March 2007; first published online 8 March 2007)
Corresponding author H. Schmidt: Carl-Ludwig-Institut für Physiologie, Liebigstrasse 27, 04103 Leipzig, Germany. Email: hartmut.schmidt{at}medizin.uni-leipzig.de

This paper has supplemental material.




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