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This Article Full Text Full Text (PDF) All Versions of this Article: 581/3/961    most recent jphysiol.2006.121822v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by de Armentia, M. L. Articles by Sah, P. Search for Related Content PubMed PubMed Citation Articles by de Armentia, M. L. Articles by Sah, P. Related Collections Neuroscience

¹ Queensland Brain Institute, University of Queensland, St Lucia, QLD 4072 Australia
² Instituto de Neurociencias de Alicante UMH-CSIC, Alicante, Spain

Glutamatergic inputs arising from the parabrachial nucleus to neurons in the lateral sector of the central amygdala were studied in vitro. Tetanic stimulation of these inputs led to LTP that did not require activation of NMDA receptors or a rise of postsynaptic calcium. LTP was accompanied by a reduction in the paired-pulse ratio, indicating that LTP results from an increase in transmitter release probability. Activation of adenylyl cyclase with forskolin potentiated these inputs with a similar reduction in paired-pulse facilitation and occluded LTP induction. LTP was inhibited by the protein kinase A blocker H89. Low-frequency stimulation led to LTD that required activation of postsynaptic NMDA receptors and a rise in postsynaptic calcium. There was no change in paired-pulse facilitation with LTD. LTD was blocked by protein phosphatase blockers calyculin and okadaic acid. We conclude that parabrachial inputs to the lateral sector of the central amygdala show presynaptic LTP that requires activation of a presynaptic protein kinase A via a calcium-dependent adenylyl cyclase while LTD at the same synapses is postsynaptic and requires a rise in postsynaptic calcium and activation of protein phosphatase.

(Received 26 September 2006; accepted after revision 22 March 2007; first published online 22 March 2007)
Corresponding author P. Sah: Queensland Brain Institute, University of Queensland, QLD 4072 Australia. Email: pankaj.sah{at}uq.edu.au

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