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This Article Full Text Full Text (PDF) Supplemental data All Versions of this Article: 582/1/263    most recent jphysiol.2007.132613v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gundlfinger, A. Articles by Breustedt, J. Search for Related Content PubMed PubMed Citation Articles by Gundlfinger, A. Articles by Breustedt, J. Related Collections Neuroscience

¹ Neurowissenschaftliches Forschungszentrum der Charité, Universitätsmedizin Berlin, Germany
² Bernstein Center for Computational Neuroscience Berlin, Germany
³ Physiologisches Institut der Universität Freiburg, Abteilung I, Freiburg, Germany

The modulation of synaptic transmission by presynaptic ionotropic and metabotropic receptors is an important means to control and dynamically adjust synaptic strength. Even though synaptic transmission and plasticity at the hippocampal mossy fibre synapse are tightly controlled by presynaptic receptors, little is known about the downstream signalling mechanisms and targets of the different receptor systems. In the present study, we identified the cellular signalling cascade by which adenosine modulates mossy fibre synaptic transmission. By means of electrophysiological and optical recording techniques, we found that adenosine activates presynaptic A₁ receptors and reduces Ca²⁺ influx into mossy fibre terminals. Ca²⁺ currents are directly modulated via a membrane-delimited pathway and the reduction of presynaptic Ca²⁺ influx can explain the inhibition of synaptic transmission. Specifically, we found that adenosine modulates both P/Q- and N-type presynaptic voltage-dependent Ca²⁺ channels and thereby controls transmitter release at the mossy fibre synapse.

(Received 17 March 2007; accepted after revision 1 May 2007; first published online 3 May 2007)
Corresponding author J. Breustedt: Neuroscience Research Centre of the Charité, Universitätsmedizin Berlin, Germany. Email: joerg.breustedt{at}charite.de

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