HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 582/2/647    most recent jphysiol.2007.128801v3 jphysiol.2007.128801v2 jphysiol.2007.128801v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cassanello, C. R. Articles by Ferrera, V. P. Search for Related Content PubMed PubMed Citation Articles by Cassanello, C. R. Articles by Ferrera, V. P. Related Collections Neuroscience

¹ Columbia University, Department of Psychiatry, Center for Neurobiology and Behaviour, and Keck-Mahoney Center for Mind and Brain, 1051 Riverside Dr, Unit 87, Kolb Research Annex 504, New York, NY 10032, USA

Signals related to eye position are essential for visual perception and eye movements, and are powerful modulators of sensory responses in many regions of the visual and oculomotor systems. We show that visual and pre-saccadic responses of frontal eye field (FEF) neurons are modulated by initial eye position in a way suggestive of a multiplicative mechanism (gain field). Furthermore the slope of the eye position sensitivity tends to be negatively correlated with preferred retinal position across the population. A model with Gaussian visual receptive fields and linear-rectified eye position gain fields accounts for a large portion of the variance in the recorded data. Using physiologically derived parameters, this model is able to subtract the gaze shift from the vector representing the retinal location of the target. This computation might be used to maintain a memory of target location in space during ongoing eye movements. This updated spatial memory can be read directly from the locus of the peak of activity across the retinotopic map of FEF and it is the result of a vector subtraction between retinal target location when flashed and subsequent eye displacement in the dark.

(Received 22 January 2007; accepted after revision 12 May 2007; first published online 17 May 2007)
Corresponding author C. R. Cassanello: Center for Neurobiology and Behavior, Columbia University, 1051 Riverside Drive, Kolb Annex 504, New York, NY 10032, USA. Email: cc2391{at}columbia.edu

This article has been cited by other articles:

				C. R. Cassanello, A. T. Nihalani, and V. P. Ferrera Neuronal Responses to Moving Targets in Monkey Frontal Eye Fields J Neurophysiol, September 1, 2008; 100(3): 1544 - 1556. [Abstract] [Full Text] [PDF]