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J Physiol Volume 583, Number 3, 855-860, September 15, 2007 DOI: 10.1113/jphysiol.2007.135889
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SYMPOSIUM REPORT

Exercise hyperaemia: is anything obligatory but the hyperaemia?

 Michael J. Joyner1 and Brad W. Wilkins1

1 Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA

Exercise can increase skeletal muscle blood flow by 100-fold over values observed at rest. As this value was 3 to 4 times higher than so-called ‘textbook’ values at the time it raised a number of issues about cardiovascular control. However, there is a continuing inability to identify the factor or combination of factors that explain this substantial increase in muscle blood flow. Moreover, these governing mechanism(s) must also explain the precise matching of muscle blood flow to metabolic demand and oxygen use or need. The difficulties identifying the mechanisms for exercise hyperaemia are especially disappointing due to the essentially concurrent discovery in the 1980s that the vascular endothelium was a key site of vasomotor control and that nitric oxide (NO) potentially released from nerves, endothelial cells, directly from tissues such as skeletal muscle, or perhaps released from red blood cells, might participate in vascular control in a way that would permit blood flow and metabolism to be closely matched.

(Received 8 May 2007; accepted after revision 16 July 2007; first published online 19 July 2007)
Corresponding author M. J. Joyner: Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. Email: joyner.michael{at}mayo.edu

This report was presented at The Journal of Physiology Symposium on Exercise hyperemia, Washington, DC, USA, 2 May 2007. It was commissioned by the Editorial Board and reflects the views of the author.




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