| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Received March 19, 2003
Revised April 11, 2003
Accepted after revision July 17, 2003
1 Harvard/Brigham and Women's Hospital
* To whom correspondence should be addressed. E-mail: mhediger{at}rics.bwh.harvard.edu.
The recently discovered apical calcium channels, CaT1 (TRPV6) and ECaC (TRPV5), belong to a family of six members called the "TRPV family". Unlike the other 4 members which are nonselective cation channels functioning as heat or osmolarity sensors in the body, CaT1 and ECaC are remarkably calcium selective channels which serve as apical calcium entry mechanisms in absorptive and secretory tissues. CaT1 is highly expressed in the proximal intestine, placenta and exocrine tissues, whereas ECaC expression is most prominent in the distal convoluted and connecting tubules of the kidney. CaT1 in the intestine is highly responsive to 1,25-dihydroxyvitamin D3 and shows both fast and slow calcium dependent feedback inhibition to prevent calcium overload. In contrast, ECaC only shows slow inactivation kinetics and appears to be mostly regulated by the calcium load in the kidney. Outside the calcium transporting epithelia, CaT1 is highly expressed in exocrine tissues such as pancreas, prostate, salivary gland. In these tissues it likely mediates re-uptake of calcium following its release by secretory vesicles. CaT1 also contributes to store-operated calcium entry in Jurkat T-lymphocytes and prostate cancer LNCaP cells, probably in conjunction with other cellular components which link CaT1 activity to the filling state of the calcium stores. Finally, CaT1 expression is upregulated in prostate cancer and other cancers of epithelial origin, highlighting its potential as a target for cancer therapy.
This article has been cited by other articles:
|
|
 |
|
  B. S. Benn, D. Ajibade, A. Porta, P. Dhawan, M. Hediger, J.-B. Peng, Y. Jiang, G. T. Oh, E.-B. Jeung, L. Lieben, et al. Active Intestinal Calcium Transport in the Absence of Transient Receptor Potential Vanilloid Type 6 and Calbindin-D9k Endocrinology, June 1, 2008; 149(6): 3196 - 3205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. J. Hoenderop and R. J. M. Bindels Calciotropic and Magnesiotropic TRP Channels Physiology, February 1, 2008; 23(1): 32 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Gao and M. G. Wheatly Molecular characterization of an epithelial Ca2+ channel-like gene from crayfish Procambarus clarkii J. Exp. Biol., May 15, 2007; 210(10): 1813 - 1824. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Montalbetti, Q. Li, Y. Wu, X.-Z. Chen, and H. F. Cantiello Polycystin-2 cation channel function in the human syncytiotrophoblast is regulated by microtubular structures J. Physiol., March 15, 2007; 579(3): 717 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Liedtke Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli J. Endocrinol., December 1, 2006; 191(3): 515 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Fuentes, J. Figueiredo, D. M. Power, and A. V. M. Canario Parathyroid hormone-related protein regulates intestinal calcium transport in sea bream (Sparus auratus) Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1499 - R1506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Woodrow, C. J. Sharpe, N. J. Fudge, A. O. Hoff, R. F. Gagel, and C. S. Kovacs Calcitonin Plays a Critical Role in Regulating Skeletal Mineral Metabolism during Lactation Endocrinology, September 1, 2006; 147(9): 4010 - 4021. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kazerounian, G. M. Pitari, F. J. Shah, G. S. Frick, M. Madesh, I. Ruiz-Stewart, S. Schulz, G. Hajnoczky, and S. A. Waldman Proliferative Signaling by Store-Operated Calcium Channels Opposes Colon Cancer Cell Cytostasis Induced by Bacterial Enterotoxins J. Pharmacol. Exp. Ther., September 1, 2005; 314(3): 1013 - 1022. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Kovacs, M. L. Woodland, N. J. Fudge, and J. K. Friel The vitamin D receptor is not required for fetal mineral homeostasis or for the regulation of placental calcium transfer in mice Am J Physiol Endocrinol Metab, July 1, 2005; 289(1): E133 - E144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. J. Hoenderop, B. Nilius, and R. J. M. Bindels Calcium Absorption Across Epithelia Physiol Rev, January 1, 2005; 85(1): 373 - 422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Niger, A Malassine, and L Cronier Calcium channels activated by endothelin-1 in human trophoblast J. Physiol., December 1, 2004; 561(2): 449 - 458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Loffing, V. Vallon, D. Loffing-Cueni, F. Aregger, K. Richter, L. Pietri, M. Bloch-Faure, J. G.J. Hoenderop, G. E. Shull, P. Meneton, et al. Altered Renal Distal Tubule Structure and Renal Na+ and Ca2+ Handling in a Mouse Model for Gitelman's Syndrome J. Am. Soc. Nephrol., September 1, 2004; 15(9): 2276 - 2288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bodding and V. Flockerzi Ca2+ Dependence of the Ca2+-selective TRPV6 Channel J. Biol. Chem., August 27, 2004; 279(35): 36546 - 36552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. V. Abeele, L. Lemonnier, S. Thebault, G. Lepage, J. B. Parys, Y. Shuba, R. Skryma, and N. Prevarskaya Two Types of Store-operated Ca2+ Channels with Different Activation Modes and Molecular Origin in LNCaP Human Prostate Cancer Epithelial Cells J. Biol. Chem., July 16, 2004; 279(29): 30326 - 30337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Voets, A. Janssens, G. Droogmans, and B. Nilius Outer Pore Architecture of a Ca2+-selective TRP Channel J. Biol. Chem., April 9, 2004; 279(15): 15223 - 15230. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
