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First published online on June 24, 2003.
 Copyright © 2003 by The Physiological Society
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Received April 12, 2003
Revised June 10, 2003
Accepted after revision June 23, 2003

Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles

Anne Garnier1*, Dominique Fortin1, Claudine Deloménie2, Iman Momken3, Vladimir Veksler3, and Renée Ventura-Clapier3

1 Cardiologie Cellulaire et Moléculaire - INSERM U446
2 IFR75-ISIT
3 Inserm U446

* To whom correspondence should be addressed. E-mail: anne.garnier{at}cep.u-psud.fr.

Congestive heart failure (CHF) induces alterations in energy metabolism and mitochondrial function that span cardiac as well as skeletal muscles. Whether these defects originate from altered mitochondrial DNA copy number and/or mitochondrial gene transcription is not known at present, nor are completely understood the factors that control mitochondrial capacity in different muscle types. We used an experimental model of CHF induced by aortic banding in the rat and investigated mitochondrial respiration and enzyme activity of biochemical mitochondrial markers in cardiac slow and fast skeletal muscles. We quantified mitochondrial DNA (mtDNA), expression of nuclear (COX IV) and mitochondrial (COX I) encoded cytochrome-c oxidase subunits as well as nuclear factors involved in mitochondrial biogenesis and in the necessary coordinated interplay between nuclear and mitochondrial genomes in health and CHF. CHF induced a decrease in oxidative capacity and mitochondrial enzyme activities with a parallel decrease in the mRNA level of COX I and IV, but no change in mtDNA content. The expression of the peroxisome proliferator activated receptor gamma co-activator 1{alpha} (PGC-1{alpha}) gene was down-regulated in CHF, as well as nuclear respiratory factor 2 and mitochondrial transcription factor A which act downstream from PGC-1{alpha}. Most interestingly, only the level of PGC-1{alpha} expression strongly correlated with muscle oxidative capacity in cardiac and skeletal muscles, both in healthy and CHF rats. Mitochondrial gene transcription is reduced in CHF, and PGC-1{alpha} appears as a potential modulator of muscle oxidative capacity under these experimental conditions.


Key words: Cardiac function • Mitogenesis • Muscle energetics




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