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First published online on June 17, 2003.
 Copyright © 2003 by The Physiological Society
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Received April 28, 2003
Revised June 3, 2003
Accepted after revision June 12, 2003

Carotid baroreflex responsiveness to head-up tilt induced central hypovolaemia: effect of aerobic fitness

Shigehiko Ogoh1*, Stefanos Volianitis2, Peter Nissen2, David Walter Wray1, Niels H Secher2, and Peter B. Raven1

1 University of North Texas Health Science Center
2 University of Copenhagen

* To whom correspondence should be addressed. E-mail: sogoh{at}hsc.unt.edu.

This investigation examined the interaction between carotid baroreflex (CBR) responsiveness during head-up tilt (HUT) induced central hypovolaemia and aerobic fitness. Seven average fit (AF), with a mean maximal oxygen uptake (VO2max) of 49 ± 1 mlO2/kg/min, and seven high fit (HF), with a VO2max of 61 ± 1 mlO2/kg/min, voluntarily participated in the investigation. After 10~15 min supine each subject was exposed to 9 levels of progressively increasing HUT by 10° increments from -20° to +60°. During the final three minutes of each stage of HUT, the CBR responsiveness was measured using a rapid pulse (500 msec) train of neck pressure (NP) and neck suction (NS) ranging from +40 to -80 Torr. The maximal gain of the carotid-HR (Gmax-HR) and carotid-MAP (Gmax-MAP) baroreflex function curves, respectively, were identified as measures of CBR responsiveness. During HUT induced decreases in thoracic admittance, an index of central blood volume (CBV), the Gmax-HR and Gmax-MAP of the AF subjects increased more than the Gmax-HR and Gmax-MAP of the HF subjects (P<0.05). The data demonstrate that the increase in the CBR responsiveness during a tilt-induced progressive unloading of the cardiopulmonary baroreceptors was attenuated in endurance-trained subjects. These findings provide an explanation for the predisposition to orthostatic hypotension and intolerance in well-trained athletes.


Key words: Blood pressure • Cardiovascular reflex • Training




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