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First published online on October 3, 2003.
 Copyright © 2003 by The Physiological Society
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Received May 25, 2003
Revised June 27, 2003
Accepted after revision October 1, 2003

Developmental aspects of spinal locomotor function: Insights from using the in vitro mouse spinal cord preparation

Patrick J Whelan1*

1 University of Calgary

* To whom correspondence should be addressed. E-mail: whelan{at}ucalgary.ca.

To date, our understanding of the circuitry that generates mammalian terrestrial walking is still poor. However, over the last five years, rapid advances have been made in our understanding of the location, function, and recently, organization of the central pattern generator (CPG) for locomotion. In the mammal, the use of the neonatal rat has largely contributed to these advances. Additionally, the use of the in vitro mouse spinal cord preparation is becoming more common, catalyzed in part, by the potential for the use of genetic approaches to study locomotor function. Although tempting, it is necessary to resist the a priori assumption that the organization of the spinal CPG is identical in the rat and mouse. This review will describe the development of locomotor-like behavior in the mouse from E12-P14. While there are still many gaps in our knowledge compared to the rat, the in vitro mouse appears to follow a qualitatively similar course of locomotor development. The emphasis in this review is the use or potential use of the mouse as a complement to existing data using the neonatal rat preparation.


Key words: Development • Locomotion • Spinal cord




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