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First published online on October 17, 2003.
 Copyright © 2003 by The Physiological Society
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Received June 30, 2003
Revised August 6, 2003
Accepted after revision October 16, 2003

Functional genomics in rodent models of hypertension

Martin W McBride1, Fadi J Charchar1, Delyth Graham1, William H Miller1, Pamela Strahorn1, Fiona J Carr1, and Anna F Dominiczak.1*

1 University of Glasgow

* To whom correspondence should be addressed. E-mail: ad7e{at}clinmed.gla.ac.uk.

Inbred strains of rodents have been used to study mammalian physiology and pathophysiology in an attempt to understand the contribution of genes in the pathogenesis of the disease process. In this review we focus on experimental animal models to identify quantitative trait loci (QTL) and possible strategies for identifying underlying genetic determinants responsible for hypertension. Confirmation of the existence of the QTL and dissection of the implicated region can be undertaken by production of either recombinant inbred, consomic or congenic strains. Despite complex interactions and the relatively few confirmed causative genes underlying QTLs, recent developments in rat genome resources and advancement in statistical and bioinformatic methods will facilitate the identification of major gene(s) responsible for complex, polygenic traits.


Key words: Gene expression • Hypertensive rats • Kidney




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