It has recently been shown that resting tremor in Parkinson's disease is associated with oscillatory neural coupling in an extensive cerebral network comprising a cerebello-diencephalic-cortical loop and cortical motor, somatosensory and posterior parietal areas contralateral to the tremor hand. The aim of the present study was to investigate whether this oscillatory brain network exclusively reflects a pathophysiological state in parkinsonian resting tremor or whether it constitutes a fundamental feature of physiological motor control. We investigated cerebro- muscular and cerebro-cerebral coupling in 11 healthy subjects imitating the typical antagonistic parkinsonian tremor. We recorded brain activity with a 122-channel whole-head neuromagnetometer and surface EMGs of the forearm extensors. Analysis of cerebro-muscular and cerebro-cerebral coherence revealed oscillatory coupling in the same brain structures that comprise the oscillatory network of parkinsonian resting tremor. Interestingly, like in parkinsonian resting tremor, the dominant frequency of cerebro-cerebral coherence was twice the simulated tremor frequency. The most striking differences between parkinsonian patients and the healthy subjects imitating the antagonistic resting tremor were a reduction of the coupling between the primary sensorimotor cortex and the diencephalic structure - most likely the thalamus - and an enhancement of the coupling between the premotor and the primary sensorimotor cortex. Our results indicate that coupling of oscillatory activity within a cerebello- diencephalic-cortical loop constitutes a basic feature of physiological motor control. Thus, our data is consistent with the hypothesis that parkinsonian resting tremor involves oscillatory cerebro-cerebral coupling in a physiologically pre-existing network.