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First published online on December 12, 2003.
 Copyright © 2003 by The Physiological Society
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Received August 19, 2003
Revised September 11, 2003
Accepted after revision December 9, 2003

Synapse-specific mGluR1-dependent long-term potentiation in interneurons regulates mouse hippocampal inhibition

Valérie Lapointe1, France Morin1, Stéphanie Ratté1, Ariane Croce1, François Conquet2, and Jean-Claude Lacaille1*

1 Département de physiologie, Université de Montréal
2 GlaxoSmithKline, Institut de Biologie Cellulaire et de Morphologie

* To whom correspondence should be addressed. E-mail: jean-claude.lacaille{at}umontreal.ca.

Hippocampal CA1 inhibitory interneurons control the excitability and synchronization of pyramidal cells, and participate in hippocampal synaptic plasticity. Pairing theta burst stimulation (TBS) with postsynaptic depolarization, we induced long-term potentiation (LTP) of putative single-fiber excitatory postsynaptic currents (EPSCs) in stratum oriens/alveus (O/A) interneurons of mouse hippocampal slices. LTP induction was absent in mGluR1 knockout mice, was correlated with the postsynaptic presence of mGluR1a, and required a postsynaptic Ca2+ rise. Changes in paired-pulse facilitation and coefficient of variation indicated that LTP expression involved presynaptic mechanisms. LTP was synapse-specific, occurring selectively at synapses modulated by presynaptic group II, but not group III, mGluRs. Furthermore, the TBS paradigm applied in O/A induced a long-term increase of polysynaptic inhibitory responses in CA1 pyramidal cells, that was absent in mGluR1 knockout mice. These results uncover the mechanisms of a novel form of interneuron synaptic plasticity that can adaptively regulate inhibition of hippocampal pyramidal cells.


Key words: Hippocampus • Interneurone • Long-term potentiation




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