| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Received October 21, 2003
Revised November 27, 2003
Accepted after revision January 23, 2004
1 University of Colorado
2 University of colorado
* To whom correspondence should be addressed. E-mail: seals{at}colorado.edu.
Peripheral conduit artery flow-mediated dilation decreases with aging in humans. The underlying mechanisms and efficacy of preventive strategies are unknown. Brachial artery flow-mediated dilation was determined at baseline, and after ascorbic acid (vitamin C) intravenous infusion and chronic supplementation (500 mg/d for 30 days) in 3 groups of healthy men: young sedentary (n=11; 25±1 years, mean±SE), older sedentary (n=9; 64±2), and older endurance exercise-trained (n=9; 64±2). At baseline, flow-mediated dilation (normalized for the hyperemic stimulus) was ~45% lower in the older (0.015±0.001) vs. young (0.028±0.004) sedentary men (p<0.01), but was preserved in older exercising men (0.028±0.004). Ascorbic acid infusion increased plasma concentrations >15-fold in all groups and restored flow-mediated dilation in the sedentary older men (to 0.023±0.002; p>0.1 vs. other groups), but did not affect flow-mediated dilation in the other 2 groups. Oral ascorbic acid supplementation did not affect flow-mediated dilation in any group. Brachial artery endothelium-independent dilation (sublingual nitroglycerin) did not differ among the groups at baseline nor change ascorbic acid administration. These results provide the first evidence for an important role of oxidative stress in the impairment in peripheral conduit artery flow-mediated dilation with sedentary human aging, and the preservation of flow-mediated dilation with physically active aging.
This article has been cited by other articles:
|
|
 |
|
  D. R. Seals, C. A. DeSouza, A. J. Donato, and H. Tanaka Habitual exercise and arterial aging J Appl Physiol, October 1, 2008; 105(4): 1323 - 1332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Csiszar, M. Wang, E. G. Lakatta, and Z. Ungvari Inflammation and endothelial dysfunction during aging: role of NF-{kappa}B J Appl Physiol, October 1, 2008; 105(4): 1333 - 1341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Donato, I. Eskurza, K. L. Jablonski, L. B. Gano, G. L. Pierce, and D. R. Seals Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans J Appl Physiol, October 1, 2008; 105(4): 1359 - 1363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Black, D. J. Green, and N. T. Cable Exercise prevents age-related decline in nitric-oxide-mediated vasodilator function in cutaneous microvessels J. Physiol., July 15, 2008; 586(14): 3511 - 3524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Pyke, V. Poitras, and M. E. Tschakovsky Brachial artery flow-mediated dilation during handgrip exercise: evidence for endothelial transduction of the mean shear stimulus Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2669 - H2679. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B Keogh, G. D Brinkworth, M. Noakes, D. P Belobrajdic, J. D Buckley, and P. M Clifton Effects of weight loss from a very-low-carbohydrate diet on endothelial function and markers of cardiovascular disease risk in subjects with abdominal obesity Am. J. Clinical Nutrition, March 1, 2008; 87(3): 567 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Shi, F. A. Schaller, N. Tierney, P. Chanthavong, S. Chen, P. B. Raven, and M. L. Smith Physically Active Lifestyle Enhances Vagal-Cardiac Function but Not Central Autonomic Neural Interaction in Elderly Humans Experimental Biology and Medicine, February 1, 2008; 233(2): 209 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Jablonski, D. R. Seals, I. Eskurza, K. D. Monahan, and A. J. Donato High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men J Appl Physiol, November 1, 2007; 103(5): 1715 - 1721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Donato, I. Eskurza, A. E. Silver, A. S. Levy, G. L. Pierce, P. E. Gates, and D. R. Seals Direct Evidence of Endothelial Oxidative Stress With Aging in Humans: Relation to Impaired Endothelium-Dependent Dilation and Upregulation of Nuclear Factor-{kappa}B Circ. Res., June 8, 2007; 100(11): 1659 - 1666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Moreau, A. R. DePaulis, K. M. Gavin, and D. R. Seals Oxidative stress contributes to chronic leg vasoconstriction in estrogen-deficient postmenopausal women J Appl Physiol, March 1, 2007; 102(3): 890 - 895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Richardson, A. J. Donato, A. Uberoi, D. W. Wray, L. Lawrenson, S. Nishiyama, and D. M. Bailey Exercise-induced brachial artery vasodilation: role of free radicals Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1516 - H1522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Donato, L. A. Lesniewski, and M. D. Delp Ageing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arterioles J. Physiol., February 15, 2007; 579(1): 115 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Schrage, J. H. Eisenach, and M. J. Joyner Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans J. Physiol., February 15, 2007; 579(1): 227 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Gates, M. L. Boucher, A. E. Silver, K. D. Monahan, and D. R. Seals Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression J Appl Physiol, January 1, 2007; 102(1): 63 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C. Kregel and H. J. Zhang An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R18 - R36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Eskurza, Z. D. Kahn, and D. R. Seals Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing J. Physiol., March 15, 2006; 571(3): 661 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Wray, A. Uberoi, L. Lawrenson, and R. S. Richardson Evidence of preserved endothelial function and vascular plasticity with age Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1271 - H1277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bell, N. R. Stob, and D. R. Seals Thermogenic responsiveness to {beta}-adrenergic stimulation is augmented in exercising versus sedentary adults: role of oxidative stress J. Physiol., February 1, 2006; 570(3): 629 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Eskurza, L. A Myerburgh, Z. D Kahn, and D. R Seals Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults J. Physiol., November 1, 2005; 568(3): 1057 - 1065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Tschakovsky and K. E. Pyke Counterpoint: Flow-mediated dilation does not reflect nitric oxide-mediated endothelial function J Appl Physiol, September 1, 2005; 99(3): 1235 - 1237. [Full Text] [PDF]
|
|
|
|
|
|
T. F. Towse, J. M. Slade, and R. A. Meyer Effect of physical activity on MRI-measured blood oxygen level-dependent transients in skeletal muscle after brief contractions J Appl Physiol, August 1, 2005; 99(2): 715 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Moreau, K. M. Gavin, A. E. Plum, and D. R. Seals Ascorbic Acid Selectively Improves Large Elastic Artery Compliance in Postmenopausal Women Hypertension, June 1, 2005; 45(6): 1107 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bell, J. M. Carson, N. W. Motte, and D. R. Seals Ascorbic acid does not affect the age-associated reduction in maximal cardiac output and oxygen consumption in healthy adults J Appl Physiol, March 1, 2005; 98(3): 845 - 849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. N. Proctor, K. U. Le, and S. J. Ridout Age and regional specificity of peak limb vascular conductance in men J Appl Physiol, January 1, 2005; 98(1): 193 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Seals and F. A. Dinenno Collateral damage: cardiovascular consequences of chronic sympathetic activation with human aging Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H1895 - H1905. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
