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Received October 21, 2003
Revised November 13, 2003
Accepted after revision March 2, 2004
1 Institute of Health and Sports Science, University of Tsukuba
2 Toyota Technological Institute
3 Faculty of Human Development, Kobe University
* To whom correspondence should be addressed. E-mail: nisiyasu{at}taiiku.tsukuba.ac.jp.
We tested the hypothesis that in humans, carotid-baroreflex dynamic responses [evaluated by examining the time course of the carotid-baroreflex-induced alterations in muscle sympathetic nerve activity (MSNA), mean arterial blood pressure (MAP) and heart rate (HR)] would be altered during mild orthostatic stress in ways that serve to limit orthostatic hypotension. In twelve healthy subjects (ten male, two female), 5 s periods of neck pressure (NP) (50mmHg) and neck suction (NS) (-60mmHg) were used to evaluate carotid baroreflex function at rest (CON) and during lower body negative pressure (LBNP) (-15mmHg). During LBNP (as compared with CON): (a) the augmentations in MSNA and MAP elicited by NP were greater, (b) the NS-induced period of MSNA suppression was, if anything, shorter, (c) the peak decrement in MAP elicited by NS, although not different in amplitude, occurred earlier and recovered to its initial level more quickly after NS, and (d) the HR responses to NP and NS were greater. These results suggest that during mild orthostatic stress, carotid-baroreflex dynamic responses are modulated in ways that should help maintain blood pressure and limit orthostatic hypotension.
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