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Received January 9, 2004
Revised February 2, 2004
Accepted after revision February 16, 2004
1 Brain Mind Institute Lausanne
2 Weizmann Institute of Science
* To whom correspondence should be addressed. E-mail: henry.markram{at}epfl.ch.
It is well established that sensory stimulation results in the activity of multiple functional columns in the neocortex. The manner in which neurons within each column are active in relation to each other is, however, not known. Multiple whole-cell recordings in activated neocortical slices revealed diverse correlation profiles of excitatory synaptic input to different types of neurons. The specific correlation profile between any two neurons could be predicted by the settings of synaptic depression and facilitation at the input synapses. Simulations further showed that patterned activity is essential for synaptic dynamics to impose the temporal dispersion of excitatory input. We propose that synaptic dynamics choreograph neuronal activity within the neocortical microcircuit in a context-dependent manner.
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