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Received March 15, 2004
Revised April 6, 2004
Accepted after revision June 4, 2004
1 Nara Women's University
* To whom correspondence should be addressed. E-mail: k.miki{at}cc.nara-wu.ac.jp.
The present study aimed to determine the impact of REM sleep and grooming on the baroreflex stimulus-response curve for renal sympathetic nerve activity (RSNA). At least 3 days before study, Wistar female rats (n=12) were chronically implanted with catheters to measure systemic arterial pressure (Pa) and to intravenously infuse vasoactive drugs. In addition, electrodes were placed for measurements of RSNA, electroencephalogram, trapezius electromyogram and electrocardiogram. The baroreflex curve for RSNA was determined by changing Pa using rapid intravenous infusions of phenylephrine and nitroprusside and then fitted to an inverse sigmoid function curve. REM sleep induced a vertical suppression of the Pa-RSNA baroreflex curve, which was characterized by significant decreases in the maximum response by 72.0 % (P<0.05) and the maximum gain by 4.02 % mmHg-1 (P<0.05) compared with NREM sleep level. Grooming shifted the Pa-RSNA baroreflex curve upward and to the right, which was associated with increases in the maximum response by 45.2 % (P<0.05), the minimum response by 20.7 % (P<0.05) and the pressure at the centering point by 11.1 mmHg (P<0.05). These data suggest that the Pa-RSNA baroreflex curve was shifted acutely and differently in a state dependent manner during natural sleep and wake cycle in rats.
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