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Received July 15, 2004
Revised August 9, 2004
Accepted after revision September 20, 2004
1 University of North Texas Health Science Center at Fort Worth
2 University of Texas Southwestern Medical Center
3 University of North Texas Health Science Center
4 UNTHSC
* To whom correspondence should be addressed. E-mail: dkeller{at}hsc.unt.edu.
Carotid baroreflex (CBR) function was examined in five men and three women (25 ± 1yrs) using the variable pressure neck collar technique at rest and during dynamic, one-legged knee extension exercise at 7W and 25W. The CBR exhibited control of leg vascular conductance (LVC) at rest and during exercise in both an exercising leg (EL) and a non-exercising leg (NEL) across a wide range of pressures from +40 Torr neck pressure (NP) to -80 Torr neck suction (NS). Specifically, increases in LVC (% change) in response to NS were no different across -20 to -80 Torr in either the EL or the NEL compared to rest, P > 0.05. However, CBR-mediated decreases in % LVC in response to NP were attenuated in the EL at both 7W (16 ± 1%) and 25W (12 ± 1%) compared to rest (40 ± 3%; P < 0.05) as well as compared to responses in the NEL (36 ± 6% at 7W and 36 ± 7% at 25W; P < 0.05). This decrease in vascular responsiveness in the EL was associated with a reduction in the gain of the percentage muscle sympathetic nerve activity (%MSNA) -%LVC relationship compared to rest (P < 0.05). Collectively, these data indicate, despite a clear attenuation of the vascular response to MSNA in the exercising leg, CBR-mediated changes in mean arterial pressure were no different between rest and exercise.
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