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First published online on September 2, 2004.
 Copyright © 2004 by The Physiological Society
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Received July 15, 2004
Revised August 4, 2004
Accepted after revision August 31, 2004

INHIBITION OF K-ATP CHANNEL ACTIVITY AUGMENTS BAROREFLEX-MEDIATED VASOCONSTRICTION IN EXERCISING SKELETAL MUSCLE

David Keller1*, Shigehiko Ogoh2, Shane Green2, A. Olivencia-Yurvati2, and Peter B. Raven3

1 University of North Texas Health Science Center at Fort Worth
2 University of North Texas Health Science Center
3 UNTHSC

* To whom correspondence should be addressed. E-mail: dkeller{at}hsc.unt.edu.

In the present investigation we sought to examine the role of ATP-sensitive potassium (KATP) channel activity in modulating carotid baroreflex (CBR) induced vasoconstriction in the vasculature of the leg. The CBR control of mean arterial pressure (MAP) and leg vascular conductance (LVC) was determined in seven subjects (25 ± 1yr, mean ± SE) using the variable pressure neck collar technique at rest and during one-legged knee extension exercise. The oral ingestion of glyburide (5mg) did not change mean arterial pressure (MAP) at rest (86 vs. 89), P > 0.05), but did appear to increase MAP during exercise (87 vs. 92), P = 0.053. However, the CBR-MAP function curves were similar at rest before and after glyburide ingestion. The CBR-mediated decreases in LVC observed at rest (~39%) was attenuated during exercise in the exercising leg (EL) (~15%), P < 0.05. Oral glyburide ingestion partially restored CBR-mediated vasoconstriction in the exercising leg (~40% restoration, P < 0.05) compared to control exercise. These findings indicate that KATP channel activity modulates sympathetic vasoconstriction in humans and may prove to be an important mechanism by which functional sympatholysis operates in humans during exercise.


Key words: ATP-sensitive potassium channel • Baroreceptor reflex • Blood flow




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