J Physiol Society Membership
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Physiology in Press

First published online on November 11, 2004.
 Copyright © 2004 by The Physiological Society
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
562/2/629    most recent
jphysiol.2004.075747v1
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Durand, S.
Right arrow Articles by Crandall, C. G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Durand, S.
Right arrow Articles by Crandall, C. G

Received September 17, 2004
Revised October 7, 2004
Accepted after revision November 8, 2004

EXOGENOUS NITRIC OXIDE INHIBITS SYMPATHETICALLY-MEDIATED VASOCONSTRICTION IN HUMAN SKIN

Sylvain Durand1, Scott L Davis1, Jian Cui1, and Craig G Crandall1*

1 Presbyterian Hospital of Dallas

* To whom correspondence should be addressed. E-mail: craigcrandall{at}texashealth.org.

Two experiments were performed to identify whether nitric oxide (NO) inhibits sympathetically-mediated vasoconstriction in human skin. In 8 subjects increasing doses of sodium nitroprusside (SNP; 8.4x10-6 to 8.4x10-3M) were administered via intradermal microdialysis. At each dose of SNP, cutaneous vasoconstrictor responsiveness was assessed during a 3-min whole-body cold stress. The relative reduction in forearm cutaneous vascular conductance (CVC) during the cold stress was significantly attenuated for SNP doses greater than 8.4x10-4M (Control: 63.0±4.1%, SNP 8.4x10-6M: 57.1±4.7%, SNP 8.4x10-5M: 57.0±3.6%, SNP 8.4x10-4M: 44.5±5.4% and SNP 8.4x10-3M: 28.8±7.9%). The second experiment was performed to identify whether this response was due to NO attenuating sympathetically mediated vasoconstriction or due to a non-specific effect of an elevated CVC secondary to SNP administration. In 7 subjects forearm CVC during a whole-body cold stress was assessed at two sites; at a site dilated via microdialysis administration of SNP and at a site dilated with isoproterenol (ISO). CVC was not different between sites prior to (SNP: 0.42±0.11; ISO: 0.46±0.11 AU/mmHg, P> 0.05) or following drug infusion (SNP: 1.36±0.21; ISO: 1.27±0.23 AU/mmHg, P> 0.05). The reduction in CVC during the subsequent cold stress was significantly less at the SNP site (38.1±6.2%) relative to the ISO site (65.0±5.5%; P=0.007). These data suggest NO is capable of inhibiting sympathetically-mediated vasoconstriction in the cutaneous vasculature.


Key words: Skin • Sympathetic activity • Thermoregulation




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
M. Shibasaki, D. A. Low, S. L. Davis, and C. G. Crandall
Nitric oxide inhibits cutaneous vasoconstriction to exogenous norepinephrine
J Appl Physiol, November 1, 2008; 105(5): 1504 - 1508.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Shibasaki, S. Durand, S. L. Davis, J. Cui, D. A. Low, D. M. Keller, and C. G. Crandall
Endogenous nitric oxide attenuates neutrally mediated cutaneous vasoconstriction
J. Physiol., December 1, 2007; 585(2): 627 - 634.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. J. Hodges, W. A. Kosiba, K. Zhao, G. E. Alvarez, and J. M. Johnson
The role of baseline in the cutaneous vasoconstrictor responses during combined local and whole body cooling in humans
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3187 - H3192.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. A. Low, M. Shibasaki, S. L. Davis, D. M. Keller, and C. G. Crandall
Does local heating-induced nitric oxide production attenuate vasoconstrictor responsiveness to lower body negative pressure in human skin?
J Appl Physiol, May 1, 2007; 102(5): 1839 - 1843.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Charkoudian, M. J. Joyner, S. A. Barnes, C. P. Johnson, J. H. Eisenach, N. M. Dietz, and B. G. Wallin
Relationship between muscle sympathetic nerve activity and systemic hemodynamics during nitric oxide synthase inhibition in humans
Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1378 - H1383.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G. J. Hodges, K. Zhao, W. A. Kosiba, and J. M. Johnson
The involvement of nitric oxide in the cutaneous vasoconstrictor response to local cooling in humans
J. Physiol., August 1, 2006; 574(3): 849 - 857.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. L. Houghton, J. R. Meendering, B. J. Wong, and C. T. Minson
Nitric oxide and noradrenaline contribute to the temperature threshold of the axon reflex response to gradual local heating in human skin
J. Physiol., May 1, 2006; 572(3): 811 - 820.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Yamazaki, R. Sone, K. Zhao, G. E. Alvarez, W. A. Kosiba, and J. M. Johnson
Rate dependency and role of nitric oxide in the vascular response to direct cooling in human skin
J Appl Physiol, January 1, 2006; 100(1): 42 - 50.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2004 The Physiological Society.