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First published online on October 21, 2004.
 Copyright © 2004 by The Physiological Society
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jphysiol.2004.076133v1
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Roland S G Jones
Gavin L Woodhall
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Received September 28, 2004
Revised October 15, 2004
Accepted after revision October 20, 2004

Background synaptic activity in rat entorhinal cortical neurones: differential control of transmitter release by presynaptic receptors

Roland S G Jones1* and Gavin L Woodhall2

1 University of Bath
2 University of Aston

* To whom correspondence should be addressed. E-mail: r.s.g.jones{at}bath.ac.uk.

The entorhinal cortex (EC) is a key brain area controlling both hippocampal input and output via neurones in layer II and layer V, respectively. It is also a pivotal area in the generation and propagation of epilepsies involving the temporal lobe. We have previously shown that within the network of the EC, neurones in layer V are subject to powerful synaptic excitation but weak inhibition, whereas the reverse is true in layer II. The deep layers are also highly susceptible to acutely provoked epileptogenesis, but the superficial layers are less likely to particiapte in such synchronized activity. Considerable evidence now points to a role of spontaneous background synaptic activity in control of neuronal, and hence network excitability. In the present article we describe results of studies where we have compared background release of the excitatory transmitter, glutamate, and the inhibitory transmitter, GABA, in the two layers, the role of this background release in the balance of excitability, and its control by presynaptic auto and heteroreceptors on presynaptic terminals.


Key words: Entorhinal cortex • Neurotransmitter release • Presynaptic




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