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Received April 29, 2005
Revised May 26, 2005
Accepted after revision July 5, 2005
rskov3,
1 Institute of Sports Medicine, Copenhagen, Denmark
2 Team Danmark Test Center, Bispebjerg Hospital, Denmark
3 Medical Research Laboratories, Aarhus University Hospital, Denmark
4 Medical & Science Development Projects, Novo Nordisk A/S, Denmark
* To whom correspondence should be addressed. E-mail: mh19{at}bbh.hosp.dk.
The purpose of this study was to examine effects of increased fat availability induced by growth hormone (GH) administration on the oxidative metabolism during exercise. Seven well-trained males [age 25 ± 2 yr (mean ± SEM), peak oxygen consumption (VO2peak): 62 ± 1 ml min-1 kg-1] completed four randomised trials; 120 min bicycling at 55 % VO2peak either four hours after receiving 7.5 IU (2.5 mg) GH or placebo (Plc), as well as during rest-trials after receiving GH or Plc, respectively. In all studies a standardized meal was given two hours after GH or Plc injection. GH-administration resulted in an increase in serum GH concentration at rest (P < 0.0001) and during exercise (P < 0.0001). The increase in serum GH was followed by an increase in circulating glycerol at rest (P < 0.0001). When combined with exercise the increase in plasma glycerol was more pronounced (GH: 716 % of baseline vs. Plc: 328 %, P < 0.0001). However, this increase in fat mobilisation did not increase fat oxidation during exercise (indirect calorimetry). In conclusion, GH-administration combined with aerobic exercise increased lipolytic parameters substantially more than exercise alone, but did not further augment whole body fat oxidation.
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