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First published online on September 1, 2005.
 Copyright © 2005 by The Physiological Society
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Received June 7, 2005
Revised July 7, 2005
Accepted after revision September 1, 2005

Photoreceptor encoding of supersaturating light stimuli in salamander retina

Jianwei Xu1, Mingli Hou2, and Malcolm M. Slaughter2*

1 University of Pennsylvania
2 University at Buffalo

* To whom correspondence should be addressed. E-mail: mslaught{at}buffalo.edu.

In the dark adapted salamander retina, spikes could be elicited from rods under normal physiological conditions. Spike activity was observed in rods during the recovery phase of the response to saturating light. These action potentials were calcium spikes, blocked by cadmium and L-type calcium channel blockers. In response to light stimuli that saturate the rod peak response, calcium action potentials occurred with a delay that depended on light intensity, with stronger light increasing spike latency. Therefore, these spikes encode rod visual information at light intensities beyond rod saturation. Postsynaptic currents of similar time course were observed in second and third order neurons. Since rods exposed to brighter light stimuli produced more delayed spike activity, these signals might contribute to negative afterimages.


Key words: Calcium action potential • Photoreceptor • Retinal rod




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