J Physiol Wellcome Trust-funded researchers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Physiology in Press

First published online on September 1, 2005.
 Copyright © 2005 by The Physiological Society
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
568/3/1057    most recent
jphysiol.2005.092734v1
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eskurza, I.
Right arrow Articles by Seals, D. R
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eskurza, I.
Right arrow Articles by Seals, D. R

Received June 16, 2005
Revised July 6, 2005
Accepted after revision August 27, 2005

Tetrahydrobiopterin Augments Endothelium-Dependent Dilation in Sedentary but Not Habitually Exercising Older Adults

Iratxe Eskurza1*, Laura A Myerburgh1, Zachary D Kahn1, and Douglas R Seals1

1 University of Colorado

* To whom correspondence should be addressed. E-mail: eskurza{at}colorado.edu.

Endothelium-dependent dilation (EDD) is impaired with aging in sedentary, but not regularly exercising adults. We tested the hypotheses that differences in BH4 bioactivity are key mechanisms explaining the impairment in EDD with sedentary aging and the maintenance of EDD with aging in regularly exercising adults. Brachial artery flow-mediated dilation (FMD), normalized for local shear stress, was measured after acute oral placebo or BH4 in young sedentary (YS) (n=10; 22±1 years, mean±SE), older sedentary (OS) (n=9; 62±2), and older habitually aerobically trained (OT) (n=12; 66±1) healthy men. At baseline, FMD was ~50 % lower in OS vs. YS [1.12±0.09 vs. 0.57±0.09 ({Delta}mm/(dyne/cm2)) x 10-2 , p<0.001], but was preserved in OT [0.93±0.08 ({Delta}mm/(dyne/cm2)) x 10-2]. BH4 administration improved FMD by ~45% in OS [1.00±0.10 ({Delta}mm/(dyne/cm2)) x 10-2, p<0.01 vs. baseline], but did not affect FMD in YS or OT. Endothelium-independent dilation neither differed between groups at baseline nor changed with BH4 administration. These results suggest that BH4 bioactivity may be a key mechanism involved in the impairment of conduit artery EDD with sedentary aging and the EDD-preserving effect of habitual exercise.


Key words: Ageing • Endothelium • Exercise




This article has been cited by other articles:


Home page
 J. Physiol.Home page
M. A. Black, D. J. Green, and N. T. Cable
Exercise prevents age-related decline in nitric-oxide-mediated vasodilator function in cutaneous microvessels
J. Physiol., July 15, 2008; 586(14): 3511 - 3524.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G. L. Pierce and T. J. LaRocca
Reduced vascular tetrahydrobiopterin (BH4) and endothelial function with ageing: is it time for a chronic BH4 supplementation trial in middle-aged and older adults?
J. Physiol., June 1, 2008; 586(11): 2673 - 2674.
[Full Text] [PDF]

Home page
 J. Physiol.Home page
K. S. Heffernan, V. J. Vieira, and R. J. Valentine
Microvascular function and ageing: L-arginine, tetrahydrobiopterin and the search for the fountain of vascular youth
J. Physiol., April 15, 2008; 586(8): 2041 - 2042.
[Full Text] [PDF]

Home page
 J. Physiol.Home page
M. D. Delp, B. J. Behnke, S. A. Spier, G. Wu, and J. M. Muller-Delp
Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles
J. Physiol., February 15, 2008; 586(4): 1161 - 1168.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
N. M. Hamburg, C. J. McMackin, A. L. Huang, S. M. Shenouda, M. E. Widlansky, E. Schulz, N. Gokce, N. B. Ruderman, J. F. Keaney Jr, and J. A. Vita
Physical Inactivity Rapidly Induces Insulin Resistance and Microvascular Dysfunction in Healthy Volunteers
Arterioscler. Thromb. Vasc. Biol., December 1, 2007; 27(12): 2650 - 2656.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. L. Jablonski, D. R. Seals, I. Eskurza, K. D. Monahan, and A. J. Donato
High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men
J Appl Physiol, November 1, 2007; 103(5): 1715 - 1721.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
Z. S. Katusic
Mechanisms of Endothelial Dysfunction Induced by Aging: Role of Arginase I
Circ. Res., September 28, 2007; 101(7): 640 - 641.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
A. J. Donato, I. Eskurza, A. E. Silver, A. S. Levy, G. L. Pierce, P. E. Gates, and D. R. Seals
Direct Evidence of Endothelial Oxidative Stress With Aging in Humans: Relation to Impaired Endothelium-Dependent Dilation and Upregulation of Nuclear Factor-{kappa}B
Circ. Res., June 8, 2007; 100(11): 1659 - 1666.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. E. Gates, M. L. Boucher, A. E. Silver, K. D. Monahan, and D. R. Seals
Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression
J Appl Physiol, January 1, 2007; 102(1): 63 - 71.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
I. Eskurza, Z. D. Kahn, and D. R. Seals
Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing
J. Physiol., March 15, 2006; 571(3): 661 - 668.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2005 The Physiological Society.