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First published online on October 6, 2005.
 Copyright © 2005 by The Physiological Society
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Received August 3, 2005
Revised September 7, 2005
Accepted after revision October 3, 2005

The effect of changes in cardiac output on the regulated middle cerebral artery mean blood velocity at rest and during exercise

Shigehiko Ogoh1*, R. Matthew Brothers1, Quinton Barnes1, Wendy L. Eubank1, Megan N. Hawkins1, Sushmita Purkayastha1, Albert O-Yurvati1, and Peter B. Raven2

1 University of North Texas Health Science Center
2 UNTHSC

* To whom correspondence should be addressed. E-mail: sogoh{at}hsc.unt.edu.

We examined the relationship between changes in cardiac output (Q) and middle cerebral artery mean blood velocity (MCA Vmean) in seven healthy volunteer men at rest and during 50% maximal oxygen uptake steady-state submaximal cycling exercise. Reductions in Q were accomplished using lower body negative pressure (LBNP), while increases in Q were accomplished using infusions of 25% human serum albumin. Heart rate (HR), arterial blood pressure (ABP) and MCA Vmean were continuously recorded. At each stage of LBNP and albumin infusion Q was measured using an acetylene rebreathing technique. Arterial blood samples were analyzed for partial pressure of carbon dioxide tension (PaCO2). During exercise HR and Q were increased above rest (P<0.001), while neither MCA Vmean nor PaCO2 were altered (P>0.05). The MCA Vmean and Q were linearly related at rest (P<0.001) and during exercise (P=0.035). The slope of the regression relationship between MCA Vmean and Q at rest was greater (P=0.035) than that observed during exercise. In addition, the phase and gain between MCA Vmean and mean arterial pressure in the low frequency range were not altered from rest to exercise indicating that the cerebral autoregulation was maintained. These data suggest that the Q associated with the changes in central blood volume influence the MCA Vmean at rest and during exercise and its regulation is independent of cerebral autoregulation. It appears that the exercise induced sympathoexcitation and the change in the distribution of Q between the cerebral circulation and the systemic circulation modifies the relationship between MCA Vmean and Q.


Key words: Arterial baroreflex • Arterial pressure • Cerebral circulation




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