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Received August 23, 2005
Revised September 26, 2005
Accepted after revision November 7, 2005
1 University of Alberta
2 University of ALberta,Faculty of Medicine and Dentistry
3 University of Alberta, Edmonton
* To whom correspondence should be addressed. E-mail: john.greer{at}ualberta.ca.
By birth, the regulatory neural network responsible for respiratory control is capable of generating robust rhythm driving ventilation that can adjust to homeostatic needs. The advent of in vitro models isolated from prenatal rodents has significantly advanced our understanding of these processes. In this topical review, we examine the development of medullary respiratory rhythm generating centres and phrenic motoneuron-diaphragm properties during the prenatal period.
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