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First published online on January 19, 2006.
Copyright © 2006 by The Physiological Society
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jphysiol.2005.099705v1
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Received October 6, 2005
Revised November 8, 2005
Accepted after revision January 18, 2006

Evaluation of Plateau-Potential Mediated 'Warm Up' In Human Motor Units

Andrew J. Fuglevand1*, Andrea P. Dutoit1, Richard K. Johns1, and Douglas A. Keen1

1 Department of Physiology, College of Medicine, University of Arizona

* To whom correspondence should be addressed. E-mail: fuglevan{at}u.arizona.edu.

Spinal motor neurons can exhibit sustained depolarization in the absence of maintained synaptic or injected current. This phenomenon, referred to as a plateau potential, is due to the activation of monoamine-dependent persistent inward currents. Accordingly, activation of a plateau potential should result in a decrease in the excitatory synaptic drive required to activate a motor unit. This, in turn, has been suggested to cause a progressive decline in the muscle force at which motor units are recruited during repeated voluntary contractions. Such a progressive decrease in threshold force associated with preceding activation of a plateau potential is referred to as 'warm up'. Furthermore, activation of a plateau potential is thought to manifest itself as a decrease in the derecruitment force compared to recruitment force. Multiple muscles, however, can contribute to the detected force and their relative contributions may vary over time which could confound measures of recruitment and derecruitment force. Therefore, the purpose of this study was to compare the recruitment and derecruitment forces of single motor units in the human extensor digitorum and tibialis anterior during repetitive triangular-force contractions in which the contributions of other muscles had been minimized. In both muscles, we found that the recruitment thresholds of single motor units were unchanged during repeated contractions, and that the derecruitment force was consistently greater than the recruitment force. These results suggest that either plateau potentials were not engaged (or were rapidly extinguished) under these experimental conditions or that changes in recruitment and derecruitment force are not suitable criteria for detecting them.


Key words: Motoneurones • Motor unit • Muscle contraction




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C.J. Heckman, M. Johnson, C. Mottram, and J. Schuster
Persistent Inward Currents in Spinal Motoneurons and Their Influence on Human Motoneuron Firing Patterns
Neuroscientist, June 1, 2008; 14(3): 264 - 275.
[Abstract] [PDF]




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