J Physiol Wellcome Trust-funded researchers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 QUICK SEARCH:   [advanced]


     


Physiology in Press

First published online on February 23, 2006.
Copyright © 2006 by The Physiological Society
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
572/3/763    most recent
jphysiol.2005.104380v1
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ahmed, B.
Right arrow Articles by Schnupp, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ahmed, B.
Right arrow Articles by Schnupp, J. W.

Received December 23, 2005
Revised February 6, 2006
Accepted after revision February 19, 2006

Response Linearity in Primary Auditory Cortex of the Ferret

Bashir Ahmed1*, Jose A Garcia-Lazaro1, and Jan WH Schnupp1

1 University of Oxford

* To whom correspondence should be addressed. E-mail: bashir.ahmed{at}physiol.ox.ac.uk.

The responses of neurons within the primary auditory cortex (A1) of the ferret elicited by broadband dynamic spectral ripple stimuli were examined over a range of ripple spectral densities and ripple velocities. The large majority of neurons showed modulated responses to these stimuli and responded most strongly at low ripple densities and velocities. The period histograms of their responses were subjected to Fourier analysis, and the ratio of the magnitudes of the f1 and f0 (DC) components of these responses were calculated to give a quantitative index of response linearity. For 82 out of 396 neurons tested (20.7%) this ratio remained above 1.0 over the entire range of ripple densities and velocities. These neurons were classified as "consistently linear". A further 134/396 (33.8%) of neurons maintained an f1/f0 ratio above 1.0 for either a range of ripple densities at a fixed ripple velocity or over a range of ripple velocities at a specific ripple density, and were classified as "locally linear". Interestingly, for the superficial layers of the primary auditory cortex consistently linear and locally linear neurons outnumbered nonlinear neurons by a 2:1 ratio. The converse was true for the deep layers. Unlike in primary visual cortex, where f1/f0 ratios have been reported to exhibit a bimodal distribution with a minimum at f1/f0 {approx} 1, f1/f0 ratios for A1 are unimodally distributed with a peak at f1/f0 {approx} 1.


Key words: Auditory system • Electrophysiology • Neocortical neurons







HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2006 The Physiological Society.