J Physiol Society Meetings
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Physiology in Press

First published online on February 9, 2006.
 Copyright © 2006 by The Physiological Society
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
572/2/459    most recent
jphysiol.2006.106617v1
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Author home page(s):
John Huguenard
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Huntsman, M. M.
Right arrow Articles by Huguenard, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huntsman, M. M.
Right arrow Articles by Huguenard, J.

Received January 31, 2006
Revised February 3, 2006
Accepted after revision February 6, 2006

Fast IPSCs in rat thalamic reticular nucleus require the GABAA receptor {beta}1 subunit

Molly Maureen Huntsman1 and John Huguenard2*

1 Georgetown University
2 Stanford University Medical Center

* To whom correspondence should be addressed. E-mail: john.huguenard{at}stanford.edu.

Synchrony within the thalamocortical system is regulated in part by intranuclear synaptic inhibition within the reticular nucleus (RTN). Inhibitory postsynaptic currents (IPSCs) in RTN neurons are largely characterized by slow decay kinetics that result in powerful and prolonged suppression of spikes. Here we show that some individual RTN neurons are characterized by highly variable mixtures of fast, slow and mixed IPSCs. Heterogeneity arose largely through differences in the contribution of a initial decay component ({tau}D ~ 10 ms) which was insensitive to loreclezole, suggesting involvement of the GABAA receptor {beta}1 subunit. Single-cell RT-PCR revealed the presence of {beta}1 subunit mRNA only in those neurons whose IPSCs were dominated by a rapid and prominent initial decay phase. These data show that brief, {beta}1-dependent, loreclezole-insensitive IPSCs are present in a subpopulation of RTN neurons, and suggest that striking differences in IPSC heterogeneity within single neurons can result from of the presence or absence of a single GABAA receptor subunit.


Key words: GABA receptor • Inhibitory postsynaptic current • Thalamus




This article has been cited by other articles:


Home page
 Cereb CortexHome page
V. C. Kotak, A. E. Takesian, and D. H. Sanes
Hearing Loss Prevents the Maturation of GABAergic Transmission in the Auditory Cortex
Cereb Cortex, September 1, 2008; 18(9): 2098 - 2108.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. M. Houston, A. M. Hosie, and T. G. Smart
Distinct Regulation of {beta}2 and {beta}3 Subunit-Containing Cerebellar Synaptic GABAA Receptors by Calcium/Calmodulin-Dependent Protein Kinase II
J. Neurosci., July 23, 2008; 28(30): 7574 - 7584.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
B. Beyer, C. Deleuze, V. A. Letts, C. L. Mahaffey, R. M. Boumil, T. A. Lew, J. R. Huguenard, and W. N. Frankel
Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4
Hum. Mol. Genet., June 15, 2008; 17(12): 1738 - 1749.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. B. Herd, A. R. Haythornthwaite, T. W. Rosahl, K. A. Wafford, G. E. Homanics, J. J. Lambert, and D. Belelli
The expression of GABAA {beta} subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells
J. Physiol., February 15, 2008; 586(4): 989 - 1004.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. M. Schofield and J. R. Huguenard
GABA Affinity Shapes IPSCs in Thalamic Nuclei
J. Neurosci., July 25, 2007; 27(30): 7954 - 7962.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Bessaih, L. Bourgeais, C. I. Badiu, D. A. Carter, T. I. Toth, D. Ruano, B. Lambolez, V. Crunelli, and N. Leresche
Nucleus-Specific Abnormalities of GABAergic Synaptic Transmission in a Genetic Model of Absence Seizures
J Neurophysiol, December 1, 2006; 96(6): 3074 - 3081.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2006 The Physiological Society.