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Received March 15, 2006
Revised March 23, 2006
Accepted after revision March 23, 2006
1 Institute for Exercise and Environmental Medicine
2 Penn State College of Medicine
3 Univ of Texas Southwestern Medical Center
* To whom correspondence should be addressed. E-mail: craigcrandall{at}texashealth.org.
The relationship between muscle sympathetic nerve activity (MSNA) and diastolic blood pressure has been used to describe two sites for arterial baroreflex control of MSNA. By determining both the likelihood of occurrence for sympathetic bursts and the area of each burst for a given diastolic blood pressure, both a 'gating' and an 'area' control site has been described in normothermic humans. Assessing the effect of heat stress on these mechanisms will improve the understanding of baroreflex control of arterial blood pressure under this thermal condition. Therefore, the purpose of this study was to test the hypothesis that heat stress enhances arterial baroreflex control of burst gating and area. In ten normotensive subjects (age, 32±2yr), MSNA (peroneal) was assessed using standard microneurographic techniques. Five-minute periods of data were examined during normothermic and whole-body heating conditions. The burst incidence (i.e. number of sympathetic bursts/100 cardiac cycles) and the area of each burst were determined for each cardiac cycle and were placed into 3 mmHg intervals of diastolic blood pressure. During normotheric conditions, there was a moderate, negative relationship between burst incidence and diastolic blood pressure (slope = -2.49 ± 0.38; r2 = 0.73 ± 0.06), while area per burst relative to diastolic blood pressure exhibited a less strong relationship (slope = -1.13 ± 0.46; r2 = 0.45 ± 0.09). During whole-body heating there was an increase in the slope of the relationship between burst incidence and diastolic blood pressure (slope = -4.69 ± 0.44; r2 = 0.84 ± 0.03) compared to normothermia (P < 0.05), while the relationship between area per burst and diastolic blood pressure was unchanged (slope = -0.92 ± 0.29; r2 = 0.41 ± 0.08) (P = 0.50). The primary finding of this investigation is that, at rest, whole-body heating enhanced arterial baroreflex control of MSNA through increased sensitivity of a 'gating' mechanism, as indicated by an increase in the slope of the relationship between burst incidence and diastolic blood pressure. This occurrence would likely help to protect against potential decreases in arterial blood pressure in an effort to preserve orthostatic tolerance during heat stress.
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