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Received April 10, 2006
Revised May 12, 2006
Accepted after revision May 16, 2006
1 Penn State College of Medicine
* To whom correspondence should be addressed. E-mail: kmonahan{at}psu.edu.
Baroreflex function is impaired in patients with obstructive sleep apnea. We tested the hypothesis that short-term exposure to repetitive hypoxic apneas (RHA) produces prolonged impairment in baroreflex function. Baroreflex function was determined using the modified Oxford technique in 14 subjects (26±1 yr). Baroreflex sensitivity (BRS) was quantified from the R-R interval-systolic blood pressure (BP: cardiovagal BRS), heart rate-systolic BP (HR BRS) and muscle sympathetic nerve activity (MSNA)-diastolic BP (sympathetic BRS) relations. RHA involved subjects performing repetitive end expiratory apneas (20 s) every minute for 30 min during intermittent hypoxia to accentuate oxygen desaturation. After RHA BP and MSNA at rest were elevated. BRS was measured 
7 (Post 1), 30 (Post 2), and 50 min (Post 3) after RHA to provide insight into the temporal pattern of responses. Cardiovagal BRS (16.8±1.3, 16.5±1.6, 17.6±2.0, and 17.4±1.5 ms/mmHg for Pre, Post 1, Post 2, and Post 3, respectively), HR BRS (-1.1±0.1, -1.1±0.1, -1.3±0.1, and -1.4±0.1 beats/min/mmHg) and sympathetic BRS (-4.5±0.6, -4.4±0.7, -3.7±0.5, and -4.7±1.0 au/beat/mmHg) were unchanged by RHA. In contrast, the operating points of the baroreflexes were shifted rightward (to higher levels of BP) and upward (to higher levels of heart rate and MSNA) after RHA (P<0.05). Time control studies performed in 5 additional subjects showed no change in any of the measured variables over time. Collectively, these data indicate that short-term exposure to RHA shifts (‘resets’) the baroreflex stimulus-response curve to higher levels of BP without influencing BRS for extended periods of time.
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