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First published online on July 27, 2006.
 Copyright © 2006 by The Physiological Society
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Received April 23, 2006
Revised May 25, 2006
Accepted after revision July 24, 2006

Heterogeneous Spatial Patterns of Long-Term Potentiation in Hippocampal Slices

Payne Y Chang1 and Meyer B. Jackson2*

1 University of Wisconsin
2 University of Wisconsin Medical School

* To whom correspondence should be addressed. E-mail: mjackson{at}physiology.wisc.edu.

Although LTP (long-term potentiation) of synaptic transmission has received much attention as a model for learning and memory, its function within a neural circuit context remains poorly understood. To monitor LTP over an extensive circuit, we imaged responses in hippocampal slices using a voltage-sensitive dye. Following theta-burst stimulation, evoked optical signals showed an increase that lasted forty minutes or more. Weak stimuli only potentiated the local area around the stimulating electrode, but stronger stimuli induced LTP over a wide area with a complex and nonuniform spatial pattern. The expression of LTP showed distinct peaks and valleys that depended on which axons were activated. Interestingly, the spatial distribution of LTP bore no relation to the spatial distribution of single-shock responses, but closely resembled the distribution of postsynaptic spikes evoked by theta bursts. Thus, post-synaptic spikes during induction constitute a critical determinant for the expression of LTP in intact circuits.


Key words: Imaging • Neural circuits • Synaptic plasticity




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