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First published online on July 6, 2006.
 Copyright © 2006 by The Physiological Society
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Received May 14, 2006
Revised June 16, 2006
Accepted after revision July 3, 2006

Transcriptional regulation of neuronal phenotype in mammals

Qiufu Ma1*

1 Dana-Farber Cancer Institute, Department of Neurobiology, Harvard Medical School

* To whom correspondence should be addressed. E-mail: qiufu_ma{at}dfci.harvard.edu.

Transcription factors (TFs) play pivotal roles in directing the formation of neurons and glia. Here I will review the recent genome-scale analysis of the expression of TFs in the developing mouse nervous system and discuss the logic by which TFs control the establishment of neuronal phenotype. Accumulating evidence suggests that while combinatorial action of TFs is able to define the basic framework of the nervous system, other control mechanisms, such as stochastic and epigenetic regulation of gene expression, also contribute to the generation of nerve cell diversity.


Key words: Development • Differentiation • Gene expression




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