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First published online on July 27, 2006.
 Copyright © 2006 by The Physiological Society
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Received June 2, 2006
Revised July 4, 2006
Accepted after revision July 26, 2006

Prestin and the cochlear amplifier

Peter Dallos1*, Jing Zheng1, and Mary Ann Cheatham1

1 Northwestern University

* To whom correspondence should be addressed. E-mail: p-dallos{at}northwestern.edu.

In non-mammalian, hair-cell bearing sense organs amplification is associated with mechano-electric transducer channels in the stereovilli (commonly called stereocilia). Because mammals possess differentiated outer hair cells (OHC), they also benefit from a novel electromotile process, powered by the motor protein, prestin. Here we consider new work pertaining to this protein and its potential role as the mammalian cochlear amplifier.


Key words: Hair Cell • Hearing




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