J Physiol Society Membership
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Physiology in Press

First published online on October 26, 2006.
 Copyright © 2006 by The Physiological Society
This Article
Right arrow Full Text (Rapid PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
578/1/259    most recent
jphysiol.2006.118448v1
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Author home page(s):
Ellen J. Yang
Alexander Z. Harris
Diana L. Pettit
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yang, E. J.
Right arrow Articles by Pettit, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yang, E. J.
Right arrow Articles by Pettit, D. L.

Received August 1, 2006
Revised September 21, 2006
Accepted after revision October 24, 2006

Synaptic kainate currents reset interneuron firing phase

Ellen J. Yang1, Alexander Z. Harris1, and Diana L. Pettit1*

1 Albert Einstein Col. of Med.

* To whom correspondence should be addressed. E-mail: dpettit{at}aecom.yu.edu.

Hippocampal interneuron activity has been linked to epileptogenesis, seizures, and the oscillatory synaptic activity detected in behaving rats. Interneurons fire at specific times in the rhythmic cycles that comprise these oscillations; however, the mechanisms controlling these firing patterns remain unclear. We have examined the role of synaptic input in modulating the firing of spontaneously active interneurons located in the stratum oriens of CA1. We find that synaptic glutamate receptor currents of 20-30 pA increase instantaneous firing frequency and reset the phase of spontaneously firing stratum oriens interneurons. Kainate receptor (KAR)-mediated currents are particularly effective at producing this phase reset, while AMPA receptor currents are relatively ineffective. The efficacy of KAR-mediated currents is probably due to their 3-fold longer decay. Given the small amplitude of the currents needed for this phase reset, coincident activation of only a few KAR-containing synapses could synchronize firing in groups of interneurons. These data suggest that KARs are potent modulators of circuit behavior and their activation alters hippocampal interneuron output.


Key words: Hippocampal neurons • Photolysis • Synchronization




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
A. Barberis, S. Sachidhanandam, and C. Mulle
GluR6/KA2 Kainate Receptors Mediate Slow-Deactivating Currents
J. Neurosci., June 18, 2008; 28(25): 6402 - 6406.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Z. Harris and D. L. Pettit
Recruiting Extrasynaptic NMDA Receptors Augments Synaptic Signaling
J Neurophysiol, February 1, 2008; 99(2): 524 - 533.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Z. Harris and D. L. Pettit
Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices
J. Physiol., October 15, 2007; 584(2): 509 - 519.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Goldin, J. Epsztein, I. Jorquera, A. Represa, Y. Ben-Ari, V. Crepel, and R. Cossart
Synaptic Kainate Receptors Tune Oriens-Lacunosum Moleculare Interneurons to Operate at Theta Frequency
J. Neurosci., September 5, 2007; 27(36): 9560 - 9572.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2006 The Physiological Society.