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First published online on September 28, 2006.
 Copyright © 2006 by The Physiological Society
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jphysiol.2006.120006v1
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Eduardo R Ropelle
José R Pauli
Patrícia O Prada
Cláudio T de Souza
Marcel C Faria
Paty K Picardi
Dennys E Cintra
Maria Fernanda A Fernandes
Marcelo B Flores
Lício A Velloso
Mário J A Saad
Jose Carvalheira
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Received August 25, 2006
Revised September 22, 2006
Accepted after revision September 25, 2006

Reversal of diet-induced insulin resistance with a single bout of exercise: The role of PTP1B and IRS-1 serine phosphorylation

Eduardo R Ropelle1, José R Pauli1, Patrícia O Prada1, Cláudio T de Souza1, Marcel C Faria1, Paty K Picardi1, Dennys E Cintra1, Maria Fernanda A Fernandes1, Marcelo B Flores1, Lício A Velloso1, Mário J A Saad1, and Jose Carvalheira1*

1 Departamento de Clínica Médica, FCM- Universidade Estadual de Campinas (UNICAMP)

* To whom correspondence should be addressed. E-mail: carvalheirajbc{at}uol.com.br.

Lifestyle interventions including exercise programs are cornerstones in the prevention of obesity-related diabetes. In this study, we demonstrate that a single bout of exercise inhibits high-fat diet-induced insulin resistance. Diet-induced obesity (DIO) increased the expression and activity of the protein tyrosine phosphatase 1B (PTP1B) and attenuated insulin signaling in gastrocnemius muscle of rats, a phenomenon which was reversed by a single session of exercise. In addition, DIO was observed to lead to serine phosphorylation of IRS-1, which was also reversed by exercise in muscle in parallel with a reduction in JNK activity. Thus, acute exercise increased the insulin sensitivity during high-fat feeding in obese rats. Overall, these results provide new insights into the mechanism by which exercise restores insulin sensitivity.


Key words: Exercise • Insulin • Obesity




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