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First published online on February 8, 2007.
 Copyright © 2007 by The Physiological Society
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Received November 8, 2006
Revised November 29, 2006
Accepted after revision February 6, 2007

Persistent inward currents in rat ventral horn neurones

Renee D. Theiss1, Jason J. Kuo1, and C. J. Heckman1*

1 Northwestern University Feinberg School of Medicine

* To whom correspondence should be addressed. E-mail: c-heckman{at}northwestern.edu.

Throughout the mammalian spinal cord, interneurones have been shown to exhibit distinct firing patterns in response to a step of injected current. In this study of ventral horn interneurones in a thick slice preparation of the lumbar cord of 11 to 19 day old rats, four distinct firing patterns were observed and classified as repetitive-firing, repetitive/burst, initial-burst or single-spiking. The hypothesis that a persistent sodium current was the predominant determinant of cell firing behaviour was investigated. A slow voltage ramp was used to assess persistent inward currents (PICs). Cells with repetitive-firing patterns had significantly larger PICs than cells displaying repetitive/burst, initial-burst or single-spiking patterns. Repetitive-firing, repetitive/burst and initial-burst firing cells were reduced to a single spiking pattern with the application of riluzole, which also markedly reduced the persistent sodium current. Persistent sodium current was found to account for most of the PIC with only a small contribution from L-type calcium current. These results suggest that the persistent sodium current plays a major role in determining firing patterns in these cells.


Key words: Electrophysiology • Interneurone • Sodium (Na+) current


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