J Physiol Society Membership
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Physiology in Press

First published online on February 22, 2007.
 Copyright © 2007 by The Physiological Society
This Article
Right arrow Full Text (Rapid PDF)
Right arrow Supplemental data
Right arrow All Versions of this Article:
581/1/139    most recent
jphysiol.2006.124321v1
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by de Kock, C. P.
Right arrow Articles by Sakmann, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by de Kock, C. P.
Right arrow Articles by Sakmann, B.

Received November 6, 2006
Revised December 21, 2006
Accepted after revision February 20, 2007

Layer and cell type specific suprathreshold stimulus representation in primary somatosensory cortex

Christiaan PJ de Kock1*, Randy M Bruno1, Hartwig Spors1, and Bert Sakmann1

1 max planck institute for medical research

* To whom correspondence should be addressed. E-mail: christiaan.dekock{at}mpimf-heidelberg.mpg.de.

Sensory stimuli are encoded differently across cortical layers and it is unknown how response characteristics relate to the morphological identity of responding cells. We therefore juxtasomally recorded action potential (AP) patterns from excitatory cells in L2/3, L4, L5 and L6 of rat barrel cortex in response to a standard stimulus (e.g. repeated deflection of single whiskers in the caudal direction). Subsequent single-cell filling with biocytin allowed for post-hoc identification of recorded cells. We report three major conclusions. First, sensory evoked responses were layer and cell type specific but always < 1 AP per stimulus, indicating low AP rates for the entire cortical column. Second, response latencies from L4, L5B and L6 were comparable and thus a whisker deflection is initially represented simultaneously in these layers. Finally, L5 thick tufted cells dominated the cortical AP output following sensory stimulation, suggesting that these cells could direct sensory guided behaviours.


Key words: Action potential • Barrel Cortex • Receptive field




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
P. Kumar and O. Ohana
Inter- and Intralaminar Subcircuits of Excitatory and Inhibitory Neurons in Layer 6a of the Rat Barrel Cortex
J Neurophysiol, October 1, 2008; 100(4): 1909 - 1922.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. Helmstaedter, B. Sakmann, and D. Feldmeyer
Neuronal Correlates of Local, Lateral, and Translaminar Inhibition with Reference to Cortical Columns
Cereb Cortex, October 1, 2008; (2008) bhn141v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Groh, C. P. J. de Kock, V. C. Wimmer, B. Sakmann, and T. Kuner
Driver or Coincidence Detector: Modal Switch of a Corticothalamic Giant Synapse Controlled by Spontaneous Activity and Short-Term Depression
J. Neurosci., September 24, 2008; 28(39): 9652 - 9663.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Helmstaedter, J. F. Staiger, B. Sakmann, and D. Feldmeyer
Efficient Recruitment of Layer 2/3 Interneurons by Layer 4 Input in Single Columns of Rat Somatosensory Cortex
J. Neurosci., August 13, 2008; 28(33): 8273 - 8284.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. P. J. de Kock and B. Sakmann
High frequency action potential bursts (>= 100 Hz) in L2/3 and L5B thick tufted neurons in anaesthetized and awake rat primary somatosensory cortex
J. Physiol., July 15, 2008; 586(14): 3353 - 3364.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. Foffani, J. K. Chapin, and K. A. Moxon
Computational Role of Large Receptive Fields in the Primary Somatosensory Cortex
J Neurophysiol, July 1, 2008; 100(1): 268 - 280.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser
Dendritic Excitability and Synaptic Plasticity
Physiol Rev, April 1, 2008; 88(2): 769 - 840.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. Pawlak and J. N. D. Kerr
Dopamine Receptor Activation Is Required for Corticostriatal Spike-Timing-Dependent Plasticity
J. Neurosci., March 5, 2008; 28(10): 2435 - 2446.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. R. Williams and S. E. Atkinson
Pathway-specific use-dependent dynamics of excitatory synaptic transmission in rat intracortical circuits
J. Physiol., December 15, 2007; 585(3): 759 - 777.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. N. D. Kerr, C. P. J. de Kock, D. S. Greenberg, R. M. Bruno, B. Sakmann, and F. Helmchen
Spatial Organization of Neuronal Population Responses in Layer 2/3 of Rat Barrel Cortex
J. Neurosci., November 28, 2007; 27(48): 13316 - 13328.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Frick, D. Feldmeyer, and B. Sakmann
Postnatal development of synaptic transmission in local networks of L5A pyramidal neurons in rat somatosensory cortex
J. Physiol., November 15, 2007; 585(1): 103 - 116.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Krieger, T. Kuner, and B. Sakmann
Synaptic Connections between Layer 5B Pyramidal Neurons in Mouse Somatosensory Cortex Are Independent of Apical Dendrite Bundling
J. Neurosci., October 24, 2007; 27(43): 11473 - 11482.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. Schubert
Observing without disturbing: how different cortical neuron classes represent tactile stimuli
J. Physiol., May 15, 2007; 581(1): 5 - 5.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2007 The Physiological Society.