Glomeruli in the vertebrate olfactory bulb (OB) appear as anatomically discrete modules receiving direct input from the olfactory epithelium (OE) via axons of olfactory receptor neurons (ORNs). The response profiles with respect to amino acids (AAs) of a large number of ORNs in larval Xenopus laevis have been recently determined and analyzed (Manzini & Schild, 2004; Schild & Manzini, 2004). Here we report on calcium imaging experiments in a nose-brain preparation of the same species at the same developmental stages. We recorded responses to AAs of glomeruli in the OB and determined the response profiles to AAs of individual glomeruli. We describe the general features of AA - responsive glomeruli and compare their response profiles to AA with those of ORNs obtained in our previous study. A large number of past studies focused either on odorant responses in the OE or on odorant - induced responses in the OB. However, a thorough comparison of odorant - induced responses of both stages, ORNs and glomeruli, of the same species is as yet lacking. The glomerular response profiles reported herein markedly differ from the previously obtained response profiles of ORNs in that glomeruli clearly have narrower selectivity profiles than ORNs. We discuss possible explanations for the different selectivity profiles of glomeruli and ORNs in the context of the development of the olfactory map.