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First published online on May 3, 2007.
 Copyright © 2007 by The Physiological Society
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jphysiol.2007.132613v1
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Received March 17, 2007
Revised April 13, 2007
Accepted after revision May 1, 2007

Adenosine modulates transmission at the hippocampal mossy fibre synapse via direct inhibition of presynaptic calcium channels

Anja Gundlfinger1, Josef Bischofberger2, Friedrich W. Johenning1, Maria Torvinen1, Dietmar Schmitz1, and Joerg Breustedt1*

1 Universitätsmedizin Berlin, Germany
2 Physiologisches Institut der Universität Freiburg, Germany

* To whom correspondence should be addressed. E-mail: joerg.breustedt{at}charite.de.

The modulation of synaptic transmission by presynaptic ionotropic and metabotropic receptors is an important means to control and dynamically adjust synaptic strength. Even though synaptic transmission and plasticity at the hippocampal mossy fibre synapse are tightly controlled by presynaptic receptors, little is known about the downstream signalling mechanisms and targets of the different receptor systems. In the present study, we identified the cellular signalling cascade by which adenosine modulates mossy fibre synaptic transmission. By means of electrophysiological and optical recording techniques, we found that adenosine activates presynaptic A1 receptors and reduces calcium influx into mossy fibre terminals. Calcium currents are directly modulated via a membrane-delimited pathway and the reduction of presynaptic calcium influx can explain the inhibition of synaptic transmission. Specifically, we found that adenosine modulates both P/Q- and N-type presynaptic voltage-dependent calcium channels and thereby controls transmitter release at the mossy fibre synapse.


Key words: Adenosine • Calcium (Ca2+) channels • Synaptic transmission




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