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First published online on July 19, 2007.
 Copyright © 2007 by The Physiological Society
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Received May 8, 2007
Revised May 31, 2007
Accepted after revision July 16, 2007

EXERCISE HYPERAEMIA: IS ANYTHING OBLIGATORY BUT THE HYPERAEMIA?

Michael J. Joyner1* and Brad W Wilkins1

1 The Mayo Clinic

* To whom correspondence should be addressed. E-mail: joyner.michael{at}mayo.edu.

Exercise hyperemia is a well known phenomenon, but the mechanisms that cause it remain poorly understood. This paper highlights a number of newly proposed ideas related to well established concepts on this topic. As has been the case for more than 100 years, relatively normal exercise hyperemia responses are observed even with experimental interventions that "block" the new mechanisms. Due to the failure to understand this fundamental biological response and because new ideas and mechanisms related to exercise hyperemia continue to emerge, many investigators are stuck between cautious nihilism and cautious optimism.


Key words: Exercise • Nitric oxide • Vasodilatation




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